NCT01366872

Brief Summary

This is a research study which is being done to determine the outcomes following Agility LP ankle replacement. This implant was approved by the FDA in 2007 and has been used since then with good early results. You are being asked to volunteer for this study because you have undergone Total Ankle Arthroplasty with Agility LP prosthesis. The purpose of the study is to compare the range of motion, level of pain and function during daily living prior to and after your ankle surgery.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
50

participants targeted

Target at P25-P50 for all trials

Timeline
Completed

Started Dec 2010

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

December 1, 2010

Completed
6 months until next milestone

First Submitted

Initial submission to the registry

June 2, 2011

Completed
4 days until next milestone

First Posted

Study publicly available on registry

June 6, 2011

Completed
1.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 1, 2012

Completed
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

September 1, 2012

Completed
4 months until next milestone

Results Posted

Study results publicly available

December 20, 2012

Completed
Last Updated

December 20, 2012

Status Verified

November 1, 2012

Enrollment Period

1.7 years

First QC Date

June 2, 2011

Results QC Date

October 16, 2012

Last Update Submit

November 20, 2012

Conditions

Keywords

anklearthritistotal ankle arthroplastyAgility LP,

Outcome Measures

Primary Outcomes (1)

  • Assessment of Functional Outcomes Following Agility LP Ankle Replacement

    Range of Motion - Combined total of dorsiflexion and plantarflexion. Full range of motion is described as 30 degrees or more. Partial limitation is described as 29 to 15 degrees. Range of motion that is less than 15 degrees is described as severely limited.

    A Minimum of 2 Years Post Index Procedure

Secondary Outcomes (2)

  • Evaluation of Complication and Reoperation Rates

    A Minimum of 2 Years Post Index Procedure

  • Radiographic Predictors of Implant Failures and Poor Outcomes

    A Minimum of 2 Years Post Index Procedure

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Female and male subjects over the age of 18 at the time of procedure who have undergone ankle joint replacement using the DePuy Agility LP Device.

You may qualify if:

  • Over 18 years old
  • Can comprehend and sign the informed consent
  • Patient must have undergone Agility LP ankle replacement between January 2006 to June 2008

You may not qualify if:

  • Patient has had following procedures on the study limb within two years of TAA
  • Revision of TAA
  • Ankle arthrodesis
  • Amputation
  • Agility LP arthroplasty was done as a revision procedure for a failed TAA or as a takedown of ankle fusion.
  • Any condition that, in the opinion of the investigator, makes the patient unsuitable for participation in the study.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Orthopaedic Associates of Michigan, PC

Grand Rapids, Michigan, 49525, United States

Location

MeSH Terms

Conditions

Arthritis

Condition Hierarchy (Ancestors)

Joint DiseasesMusculoskeletal Diseases

Results Point of Contact

Title
Dr. John G. Anderson
Organization
Orthopaedic Associates of Michigan, PC

Study Officials

  • John G Anderson, MD

    Orthopaedic Associates of Michigan, PC

    PRINCIPAL INVESTIGATOR

Publication Agreements

PI is Sponsor Employee
No
Restrictive Agreement
No

Study Design

Study Type
observational
Observational Model
CASE ONLY
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

June 2, 2011

First Posted

June 6, 2011

Study Start

December 1, 2010

Primary Completion

August 1, 2012

Study Completion

September 1, 2012

Last Updated

December 20, 2012

Results First Posted

December 20, 2012

Record last verified: 2012-11

Locations