COPE-Co-morbidities, Parkinson's Disease and Exercise
COPE
1 other identifier
interventional
58
1 country
1
Brief Summary
Problems with balance and walking that affect mobility are an inevitable cause of decreased quality of life in older people with chronic neurologic conditions such as Parkinson's disease (PD). Although there is evidence that exercise can improve mobility in the elderly, the investigators don't know: 1) What is the best mode of exercise intervention delivery (i.e. individual therapy in a clinic, home exercise program, or a group class)? and 2) how do other problems common in people with PD and/or the elderly affect outcomes? Although most physical therapy is carried out individually, a group or home program would be most cost-effective so the investigators need to know if they are just as effective. Since most older people with chronic neurologic diseases also have other problems affecting mental function, muscles and joints and/or pain, it is important to understand how these other problem affect the success of their therapy. The purpose of this study is to investigate how PT intervention should be delivered to patients with chronic neurologic disease who also have other problems. The investigators will using elderly people with PD who have one or more co-morbidities associated with PD and/or aging. Sixty people PD and co-morbidities will be randomized into 1of 3 groups; home program, individual PT or group exercise class. Each of the 3 groups will be led by the same PT providing a novel sensory-motor agility program developed by our laboratory. All groups will perform the same type of exercises 3 X/week for 4 weeks. Improvement in the Physical Performance Test of disability will be used to determine the success of therapy. To determine how and why mobility was improved by therapy, changes in gait, balance, and quality of life will be measured. Gait and balance will be measured with new, wearable motion sensors (iPOD size) while standing up from a chair, walking, turning around and sitting back down. The findings from this study will help guide rehabilitation treatment for complex , chronic problems affecting mobility in older people.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Mar 2011
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 1, 2011
CompletedFirst Submitted
Initial submission to the registry
May 17, 2011
CompletedFirst Posted
Study publicly available on registry
May 27, 2011
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 1, 2012
CompletedStudy Completion
Last participant's last visit for all outcomes
August 1, 2012
CompletedOctober 9, 2017
October 1, 2017
1.4 years
May 17, 2011
October 6, 2017
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Physical Performance Test
4 weeks
Secondary Outcomes (8)
UPDRS ADL and Motor UPDRS ADL and Motor
4 wks
Timed up and Go Test with and without DT
4 wks
Gait analysis
4 wks
MiniBESTest
4 wks
PDQ-39
4 wks
- +3 more secondary outcomes
Study Arms (3)
One on one with a PT
OTHERThe participant will work one-on-one with a trained for PT for 3 days a week for four weeks.
Group exercise class
OTHERThe participant will be in a group exercise class. That will meet 3 days a week for 4 weeks.
Home Program
OTHERThe participant will meet one time with a physical therapist and will be given a home program--which is standard of care--to follow for 4 weeks.
Interventions
Physical therapy program for people with PD--one on one with a PT
The participant will be in an exercise class for 3 days a week for 4 weeks.
The participant will meet one time with a physical therapist and will be given a home program--which is standard of care--to follow for 4 weeks.
Eligibility Criteria
You may qualify if:
- Diagnosis of Idiopathic Parkinson's disease
You may not qualify if:
- Outside of the age range
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
OHSU
Portland, Oregon, 97239, United States
Related Publications (1)
King LA, Priest KC, Nutt J, Chen Y, Chen Z, Melnick M, Horak F. Comorbidity and functional mobility in persons with Parkinson disease. Arch Phys Med Rehabil. 2014 Nov;95(11):2152-7. doi: 10.1016/j.apmr.2014.07.396. Epub 2014 Aug 4.
PMID: 25102383DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Laurie King, PhD
Oregon Health and Science University
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Assistant Professor of Neurology
Study Record Dates
First Submitted
May 17, 2011
First Posted
May 27, 2011
Study Start
March 1, 2011
Primary Completion
August 1, 2012
Study Completion
August 1, 2012
Last Updated
October 9, 2017
Record last verified: 2017-10