Long-tErm Follow-uP of antithrombotIc Management Patterns In Acute CORonary Syndrome Patients in Asia

NCT01361386 | Completed

• 1 other identifier: NIS-CAP-XXX-2011/1
• Study Type: observational
• Target: 13,011
• Locations: 7 countries
• Sites: 108

Brief Summary

The purpose of this study is to describe the short-and long-tern (i.e. up to 2 years following the index event) AMPs in patients hospitalized for an acute coronary syndrome (i.e. STEMI or NSTE-ACS), and to document clinical outcomes, economic aspects and impact on quality of life of these AMPs in a 'real-life' setting.

Conditions

Acute Coronary Syndrome

Keywords

Long-term follow up; Antithrombotic management patterns; Acute Coronary Syndrome; Asia; quality of life

Outcome Measures

Primary Outcomes (1)

• short- and long-term medication and treatment prescribed by physicians in real-life setting

  up to 3 years

Secondary Outcomes (3)

• clinical outcome (Cardiovascular events)

  up to 3 years

• cost of hospitalization

  up to 3 years

• quality of life (EQ-5D questionnaire)

  up to 3 years

Study Arms (1)

1

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Asian patients hospitalized for ACS within 48 hours of symptom onset and who have a final diagnosis of unstable angina (UA), STEMI or non-ST-segment elevation myocardial infarction (NSTEMI).

You may qualify if:

• Written informed consent has been provided.
• Diagnosis of STEMI, NSTEMI or UA
• Hospitalization for the first time within 48 hours of onset of symptoms.

You may not qualify if:

• UA, STEMI, NSTEMI precipitated by or as a complication of surgery, trauma, or GI bleeding or post-PCI UA, STEMI and NSTEMI occurring in patients already hospitalized for other reasons.
• Current participation in a randomised interventional clinical trial.

Sponsors & Collaborators

• AstraZeneca: lead

Study Sites (108)

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Hefei, Anhui, China

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Wuhu, Anhui, China

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Beijing, Beijing Municipality, China

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Chongqing, Chongqing Municipality, China

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Fuzhou, Fujian, China

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Lanzhou, Gansu, China

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Foshan, Guangdong, China

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Guangzhou, Guangdong, China

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Shenzhen, Guangdong, China

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Nanning, Guangxi, China

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Yulin, Guangxi, China

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Guiyang, Guizhou, China

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Baoding, Hebei, China

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Shijiazhuang, Hebei, China

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Tangshan, Hebei, China

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Daqing, Heilongjiang, China

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Harbin, Heilongjiang, China

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Zhengzhou, Henan, China

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Shiyan, Hubei, China

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Wuhan, Hubei, China

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Changsha, Hunan, China

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Nanjing, Jiangsu, China

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Wuxi, Jiangsu, China

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Xuzhou, Jiangsu, China

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Zhenjiang, Jiangsu, China

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Changchun, Jilin, China

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Jinzhou, Liaoning, China

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Shenyang, Liaoning, China

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Yingkou, Liaoning, China

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Xining, Qinghai, China

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Xi'an, Shaanxi, China

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Jinan, Shandong, China

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Shanghai, Shanghai Municipality, China

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Changzhi, Shanxi, China

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Jinzhong, Shanxi, China

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Taiyuan, Shanxi, China

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Chengdu, Sichuan, China

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Tianjin, Tianjin Municipality, China

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Shihezi, Xinjiang, China

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Urumuqi, Xinjiang, China

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Kunming, Yunnan, China

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Hangzhou, Zhejiang, China

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Hong Kong, China

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Ningxia, China

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Qingdao, China

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Hyderabad, Andhra Pradesh, India

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Guwahati, Assam, India

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Ahmedabad, Gujarat, India

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Surat, Gujarat, India

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Vadodara, Gujarat, India

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Gurgaon, Haryana, India

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Bangalore, Karnataka, India

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Manipal, Karnataka, India

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Kochi, Kerala, India

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Trivandrum, Kerala, India

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Bhopal, Madhya Pradesh, India

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Bilāspur, Madhya Pradesh, India

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Aurangabad, Maharashtra, India

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Mumbai, Maharashtra, India

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Nagpur, Maharashtra, India

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Pune, Maharashtra, India

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Delhi, National Capital Territory of Delhi, India

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Ludhiana, Punjab, India

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Mohali, Punjab, India

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Ajmer, Rajasthan, India

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Jaipur, Rajasthan, India

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Chennai, Tamil Nadu, India

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Coimbatore, Tamil Nadu, India

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Madurai, Tamil Nadu, India

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Lucknow, Uttar Pradesh, India

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Kolkata, West Bengal, India

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Sarawak, Kuching, Malaysia

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George Town, Malaysia

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Singapore, Singapore

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Busan, Busan, South Korea

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Chuncheon, Chuncheon, South Korea

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Cheonan, Chungcheongnam-do, South Korea

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Deagu, Deagu, South Korea

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Gwangju, Gwangju, South Korea

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Bucheon-si, Gyeonggi-do, South Korea

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Goyang-si, Gyeonggi-do, South Korea

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Suwon, Gyeonggi-do, South Korea

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Yangsan, Gyeongsangnam-do, South Korea

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Jeju City, Jeju-do, South Korea

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Iksan, Jeollabuk-do, South Korea

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Seoul, Seoul, South Korea

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Bangkoknoi, Bangkok, Thailand

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Huaykwang, Bangkok, Thailand

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PathumWan, Bangkok, Thailand

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Payathai, Bangkok, Thailand

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Rachathevi, Bangkok, Thailand

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Saimai, Bangkok, Thailand

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Muang, Changwat Chanthaburi, Thailand

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Muang, Changwat Chon Buri, Thailand

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Muang, Changwat Lampang, Thailand

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Muang, Changwat Nan, Thailand

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Klongluang, Changwat Pathum Thani, Thailand

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Muang, Changwat Phitsanulok, Thailand

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Muang, Changwat Songkhla, Thailand

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Muang, Changwat Suphan Buri, Thailand

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Muang, Changwat Surat Thani, Thailand

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Muang, Chiangmai, Thailand

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Muang, Chiangrai, Thailand

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Muang, Khonkaen, Thailand

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Muang, Nakornratchaseema, Thailand

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Muang, Udonthani, Thailand

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Ho Chi Minh City, Ho Chi Minh City, Vietnam

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Huế, Hue, Vietnam

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Related Publications (4)

• Huo Y, Van de Werf F, Han Y, Rossello X, Pocock SJ, Chin CT, Lee SW, Li Y, Jiang J, Vega AM, Medina J, Bueno H. Long-Term Antithrombotic Therapy and Clinical Outcomes in Patients with Acute Coronary Syndrome and Renal Impairment: Insights from EPICOR and EPICOR Asia. Am J Cardiovasc Drugs. 2021 Jul;21(4):471-482. doi: 10.1007/s40256-020-00447-5. Epub 2021 Feb 4.

  PMID: 33537947 DERIVED

• Guan S, Xu X, Li Y, Li J, Guan M, Wang X, Jing Q, Huo Y, Han Y. Impact of Diabetes Mellitus on Antithrombotic Management Patterns and Long-Term Clinical Outcomes in Patients With Acute Coronary Syndrome: Insights From the EPICOR Asia Study. J Am Heart Assoc. 2020 Nov 17;9(22):e013476. doi: 10.1161/JAHA.119.013476. Epub 2020 Nov 7.

  PMID: 33164633 DERIVED

• Zhang S, Wang W, Sawhney JPS, Krittayaphong R, Kim HS, Nhan VT, Lee SW, Ong TK, Chin CT, Pocock SJ, Huo Y, Qian J, Ge J. Antithrombotic management and long-term outcomes following percutaneous coronary intervention for acute coronary syndrome in Asia. Int J Cardiol. 2020 Jul 1;310:16-22. doi: 10.1016/j.ijcard.2020.01.008. Epub 2020 Mar 17.

  PMID: 32192746 DERIVED

• Jan S, Lee SW, Sawhney JPS, Ong TK, Chin CT, Kim HS, Krittayaphong R, Nhan VT, Pocock SJ, Vega AM, Hayashi N, Huo Y. Predictors of high-cost hospitalization in the treatment of acute coronary syndrome in Asia: findings from EPICOR Asia. BMC Cardiovasc Disord. 2018 Jul 4;18(1):139. doi: 10.1186/s12872-018-0859-4.

  PMID: 29973147 DERIVED

MeSH Terms

Conditions

Acute Coronary Syndrome

Condition Hierarchy (Ancestors)

Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases

Study Officials

• Guy Yeoman

  AstraZeneca

  STUDY DIRECTOR

• Prof. Huo Yong

  Peking University 1st Hospital

  STUDY CHAIR

• Jayanti Visvanathan

  AstraZeneca

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 23, 2011
• First Posted: May 26, 2011
• Study Start: June 1, 2011
• Primary Completion: May 1, 2014
• Study Completion: May 1, 2014
• Last Updated: June 16, 2014

Record last verified: 2014-06

Locations

VN (2); KR (12); MY (2); CN (45); IN (26); SG (1); TH (20)