NCT01358916

Brief Summary

Antimicrobial resistance has become a world-wide problem and antibiotic consumption is a major driving force for the development of resistance. Thus optimization of antibiotic prescription and reduction of unnecessary antimicrobial treatment are essential in the prevention and reduction of antimicrobial resistance rates. The goal of this study is the improvement of antibiotic prescription in outpatient care. The study will take place within a Swiss-wide sentinel surveillance network of physicians. The participating physicians will be randomised in a control and intervention group. The intervention group will receive therapeutic guidelines for the treatment of upper and lower respiratory tract infections and lower urinary tract infection as well as regular feed-backs on the prescription pattern of the sentinel physicians during the past months. Sentinel physicians will collect information about each antibiotic prescription, its indication and characteristics of the patient. Our hypothesis is that the prescription pattern in the intervention group will be optimised and unnecessary antibiotic therapy will be reduced compared to the control group.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
140

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Nov 2010

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

November 1, 2010

Completed
7 months until next milestone

First Submitted

Initial submission to the registry

May 19, 2011

Completed
5 days until next milestone

First Posted

Study publicly available on registry

May 24, 2011

Completed
1.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2012

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2012

Completed
Last Updated

March 29, 2013

Status Verified

March 1, 2013

Enrollment Period

2.1 years

First QC Date

May 19, 2011

Last Update Submit

March 27, 2013

Conditions

Respiratory Tract InfectionsUrinary Tract Infections

Keywords

antimicrobial resistanceantibiotic prescriptionprimary health carecluster-randomized trial

Outcome Measures

Primary Outcomes (2)

  • Percentage of prescriptions of penicillin for respiratory tract infections

    Two years

  • Percentage of prescriptions of TMP/SMX for lower urinary tract infections in adults

    Two years

Secondary Outcomes (2)

  • Percentage of prescriptions of quinolone for COPD exacerbations in adults

    Two years

  • Percentage of antibiotic prescriptions for the indications "sinusitis" and "other upper respiratory tract infections"

    Two years

Study Arms (2)

Usual information policy

NO INTERVENTION

No specific intervention

Antibiotic therapy guidelines

OTHER
Other: Mailing of antibiotic therapy guidelines to the sentinel physicians

Interventions

Mailing of antibiotic therapy guidelines to the sentinel physiciansOTHER

Mailing of antibiotic therapy guidelines to the sentinel physicians and regular feedback on antibiotic prescription

Antibiotic therapy guidelines

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

  • Patients with respiratory tract infections or urinary tract infections

You may not qualify if:

  • Patients with chronic disease requiring regular antibiotic treatment

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Institute for Infectious Diseases

Bern, 3010, Switzerland

Location

Related Publications (1)

  • Hurlimann D, Limacher A, Schabel M, Zanetti G, Berger C, Muhlemann K, Kronenberg A; Swiss Sentinel Working Group. Improvement of antibiotic prescription in outpatient care: a cluster-randomized intervention study using a sentinel surveillance network of physicians. J Antimicrob Chemother. 2015 Feb;70(2):602-8. doi: 10.1093/jac/dku394. Epub 2014 Oct 17.

    PMID: 25326088DERIVED

MeSH Terms

Conditions

Respiratory Tract InfectionsUrinary Tract Infections

Condition Hierarchy (Ancestors)

InfectionsRespiratory Tract DiseasesUrologic DiseasesFemale Urogenital DiseasesFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital DiseasesMale Urogenital Diseases

Study Officials

  • Andreas Kronenberg, Dr. med.

    University of Bern

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

May 19, 2011

First Posted

May 24, 2011

Study Start

November 1, 2010

Primary Completion

December 1, 2012

Study Completion

December 1, 2012

Last Updated

March 29, 2013

Record last verified: 2013-03

Locations

CH(1)