NCT01353196|CompletedResults
Asymptomatic Carotid Stenosis: Cognitive Function and Plaque Correlates
ACCOF
Loading search results
ACCOF
Sponsor study identifier
observational
170
1 country
1
Study Start
May 15, 2011
Actual (reported)Primary Completion
February 28, 2018
Actual (reported)Study Completion
February 28, 2018
Actual (reported)Carotid artery plaques are known to cause stroke. Cognitive impairment is an insidious but poorly understood problem in patients with carotid plaques. Cognitive function describes how people perform mental processes such as thinking, learning and problem solving. Asymptomatic carotid plaques may affect 1 million Veterans who may be at risk for cognitive impairment. In this study, the investigators will uncover the extent of cognitive impairment in Veterans with carotid stenosis who are currently labeled "asymptomatic". Programs to prevent or mitigate cognitive impairment will depend on identifying the mechanisms by which this occurs. The investigators will use sophisticated 3D imaging techniques developed by the group to measure the structure and composition of plaques, number of particles breaking off from them, blood levels of chemicals that could disrupt them, and blood flow restriction to the brain from them. This will help identify patients at risk for cognitive impairment who may benefit from preventative measures and improve selection of patients to decrease unnecessary surgical procedures.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
February 28, 2018
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
May 11, 2011
Actual (reported)May 12, 2011
Actual (reported)May 15, 2011
Actual (reported)February 28, 2018
Actual (reported)February 28, 2018
Actual (reported)July 24, 2019
Actual (reported)Composite Cognitive Score
composite of multiple cognitive function test scores scores are reported as mean +/- standard deviation 0 = worst 100 = best
2 years
carotid stenosis
no stenosis
Patients eligible for the study will have asymptomatic \>=50% carotid stenosis
Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD
Baltimore, Maryland, 21201, United States
Lal BK, Dux MC, Sikdar S, Goldstein C, Khan AA, Yokemick J, Zhao L. Asymptomatic carotid stenosis is associated with cognitive impairment. J Vasc Surg. 2017 Oct;66(4):1083-1092. doi: 10.1016/j.jvs.2017.04.038. Epub 2017 Jul 14.
blood samples for inflammatory markers
Brajesh K Lal, MD
Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD
170 participants (actual enrollment reported by the registry).
First Submitted
May 11, 2011
First Posted
May 12, 2011
Study Start
May 15, 2011
Actual (reported)Prophylaxis Against Malaria to Enhance Child Development (PROTECT Study)
Contact the study team to confirm eligibility.
Primary Completion
February 28, 2018
Actual (reported)Study Completion
February 28, 2018
Actual (reported)Last Updated
July 24, 2019
Results First Posted
July 24, 2019
Record last verified: 2019-05
Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.
Source: ClinicalTrials.gov.
JSON downloads include source attribution and retrieval details alongside the unchanged original record or the separately normalized values.
Source retrieved: