NCT01349946|Completed
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Sponsor study identifier
Secondary identifiers
NIH
observational
138
1 country
7
Study Start
June 2008
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
September 2011
Actual (reported)Study Completion
December 2011
Actual (reported)Diffusion and Perfusion Imaging Evaluation for Understanding Stroke Evolution Study 2 (DEFUSE 2) is a multi-center pilot study to determine if cerebral perfusion imaging can help identify which patients, who are ineligible for intravenous tissue plasminogen activator (iv tPA) therapy or have failed iv tPA therapy, are most likely to benefit from an endovascular clot removal procedure.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 2011
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
June 2008
Date type not reportedThis date has not been verified as actual or estimated.
May 5, 2011
Actual (reported)May 9, 2011
Actual (reported)September 2011
Actual (reported)December 2011
Actual (reported)NIHSS Score
30 days
Modifies Rankin Score
90 days
population includes those people with acute ischemic stroke
Stanford University School of Medicine
Stanford, California, 94305, United States
The Queen
Honolulu, Hawaii, United States
Northwestern University
Chicago, Illinois, United States
Oregon Health Sciences University
Portland, Oregon, United States
University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, United States
University of Utah
Salt Lake City, Utah, United States
Swedish Hospital
Seattle, Washington, United States
Lansberg MG, Straka M, Kemp S, Mlynash M, Wechsler LR, Jovin TG, Wilder MJ, Lutsep HL, Czartoski TJ, Bernstein RA, Chang CW, Warach S, Fazekas F, Inoue M, Tipirneni A, Hamilton SA, Zaharchuk G, Marks MP, Bammer R, Albers GW; DEFUSE 2 study investigators. MRI profile and response to endovascular reperfusion after stroke (DEFUSE 2): a prospective cohort study. Lancet Neurol. 2012 Oct;11(10):860-7. doi: 10.1016/S1474-4422(12)70203-X. Epub 2012 Sep 4.
Yu Y, Christensen S, Ouyang J, Scalzo F, Liebeskind DS, Lansberg MG, Albers GW, Zaharchuk G. Predicting Hypoperfusion Lesion and Target Mismatch in Stroke from Diffusion-weighted MRI Using Deep Learning. Radiology. 2023 Apr;307(1):e220882. doi: 10.1148/radiol.220882. Epub 2022 Dec 6.
Gregory W Albers
Stanford University
138 participants (actual enrollment reported by the registry).
First Submitted
May 5, 2011
First Posted
May 9, 2011
Study Start
June 2008
Date type not reportedThis date has not been verified as actual or estimated.
Understanding Different Parameters in Locomotor Training (a Type of Walking Training) for Person After a Stroke
Contact the study team to confirm eligibility.
Marks MP, Lansberg MG, Mlynash M, Olivot JM, Straka M, Kemp S, McTaggart R, Inoue M, Zaharchuk G, Bammer R, Albers GW; Diffusion and Perfusion Imaging Evaluation for Understanding Stroke Evolution 2 Investigators. Effect of collateral blood flow on patients undergoing endovascular therapy for acute ischemic stroke. Stroke. 2014 Apr;45(4):1035-9. doi: 10.1161/STROKEAHA.113.004085. Epub 2014 Feb 25.
Primary Completion
September 2011
Actual (reported)Study Completion
December 2011
Actual (reported)Last Updated
April 14, 2016
Record last verified: 2016-04
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Source: ClinicalTrials.gov.
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