The Correlation Between B-type Natriuretic Peptide (BNP) and Global End Diastolic Volume

NCT01344265 | Completed

• 1 other identifier: zh_zhang1984
• Study Type: observational
• Target: 46
• Locations: 1 country
• Sites: 1

Brief Summary

The investigators hypothesized that the serum B-type Natriuretic Peptide (BNP) level may be correlated with global end diastolic volume (GEDV) as measured by transpulmonary thermodilution technique (PiCCO). The rationale is that some animal studies have proven that BNP is released from ventricular myocardium in response to physical expansion. Such physical expansion can be measured by GEDV. If the hypothesis can be confirmed with our study, the serum level BNP can be used to monitor volume status of critically ill patient, instead of the invasive monitoring system.

Conditions

Critically Ill

Keywords

B-type natriuretic peptide; global end diastolic volume

Outcome Measures

Primary Outcomes (1)

• global end diastolic volume

  this is measured by transpulmonary thermodilution technique

  within 12 h after measurement of BNP

Study Arms (1)

consecutive patients

there is only one group in our study

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

critically ill patients who required hemodynamic monitoring using PiCCO

You may qualify if:

• critically ill patients who required hemodynamic monitoring using PiCCO

You may not qualify if:

• patients with renal dysfunction
• those older than 80 years
• pregnant women

Sponsors & Collaborators

• Jinhua Central Hospital: lead

Study Sites (1)

Jinhua central hospital

Jinhua, Zhejiang, 321000, China

Location

MeSH Terms

Conditions

Critical Illness

Condition Hierarchy (Ancestors)

Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Zhongheng Zhang, MD

  Jinhua Central Hospital

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr.

Study Record Dates

• First Submitted: April 27, 2011
• First Posted: April 29, 2011
• Study Start: June 1, 2010
• Primary Completion: October 1, 2011
• Study Completion: October 1, 2011
• Last Updated: April 4, 2013

Record last verified: 2012-09

Locations

CN (1)