NCT01332357

Brief Summary

The objective of this study is to compare readmission to the emergency department for asthma in asthma patients who receive treatment with fluticasone propionate and salmeterol oral inhaler after an initial emergency department visit using a retrospective observational cohort study design.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
6,139

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jun 2009

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

June 1, 2009

Completed
1.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 1, 2010

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

July 1, 2010

Completed
9 months until next milestone

First Submitted

Initial submission to the registry

April 7, 2011

Completed
4 days until next milestone

First Posted

Study publicly available on registry

April 11, 2011

Completed
6 months until next milestone

Results Posted

Study results publicly available

October 13, 2011

Completed
Last Updated

July 6, 2017

Status Verified

June 1, 2017

Enrollment Period

1.1 years

First QC Date

April 7, 2011

Results QC Date

September 8, 2011

Last Update Submit

June 6, 2017

Conditions

Keywords

fluticasone/propionate salmeterol combinationhospitalizationemergency departmentasthma

Outcome Measures

Primary Outcomes (1)

  • Number of Participants With an Asthma-related Event Occurring Between 1 and 6 Months Following the Index Event

    A subsequent asthma-related inpatient (IP) visit or emergency department (ED) visit were defined as visits within 6 months of the index event. The index event was defined as an asthma-related hospitalization or ED visit occuring between 2004 and 2008.

    Data were collected during a 4-year period from January 1, 2004 to December 31, 2008.

Study Arms (2)

Fluticasone propionate/salmeterol combination ED MD

Asthma subjects discharged from an institution after treatment for severe asthma exacerbation that receive fluticasone propionate/salmeterol combination from the ED physician

Drug: Fluticasone propionate/salmeterol combination ED MD

Fluticasone propionate/salmeterol combination OP MD

Asthma subjects discharged from an institution after treatment for severe asthma exacerbation that receive fluticasone propionate/salmeterol combination from the OP physician

Drug: Fluticasone propionate/salmeterol combination OP MD

Interventions

Receipt of fluticasone propionate/salmeterol combination from the ED physician

Fluticasone propionate/salmeterol combination ED MD

Receipt of fluticasone propionate/salmeterol combination from the OP physician

Fluticasone propionate/salmeterol combination OP MD

Eligibility Criteria

Age12 Years+
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

The study intends to identify subjects with asthma discharged from an emergency department that received fluticasone propionate/salmeterol from either an ED physician or from an outpatient physician

You may qualify if:

  • Subjects with asthma as determined by ICD-9 codes and asthma drug use
  • at least 12 years of age
  • discharged from an initial Emergency Department visit within 12 months

You may not qualify if:

  • Subjects with COPD or treatment for COPD

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

AsthmaEmergencies

Interventions

Fluticasone

Condition Hierarchy (Ancestors)

Bronchial DiseasesRespiratory Tract DiseasesLung Diseases, ObstructiveLung DiseasesRespiratory HypersensitivityHypersensitivity, ImmediateHypersensitivityImmune System DiseasesDisease AttributesPathologic ProcessesPathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

AndrostadienesAndrostenesAndrostanesSteroidsFused-Ring CompoundsPolycyclic Compounds

Results Point of Contact

Title
GSK Response Center
Organization
GlaxoSmithKline

Study Officials

  • GSK Clinical Trials

    GlaxoSmithKline

    STUDY DIRECTOR

Publication Agreements

PI is Sponsor Employee
No
Restriction Type
OTHER
Restrictive Agreement
Yes

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
RETROSPECTIVE
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

April 7, 2011

First Posted

April 11, 2011

Study Start

June 1, 2009

Primary Completion

July 1, 2010

Study Completion

July 1, 2010

Last Updated

July 6, 2017

Results First Posted

October 13, 2011

Record last verified: 2017-06