Modification of Cerebral Activity of Obsessive Compulsive Disorder (OCD) Patients During Cognitive and Behavioral Therapy

NCT01331876 | Completed DMC

• 2 other identifiers: C09-022009-A00652-55
• Study Type: interventional
• Target: 35
• Locations: 1 country
• Sites: 1

Brief Summary

Obsessive compulsive Disorder (OCD) is a frequent psychiatric disorder. Obsessions and compulsions are the two manifestations of this disease. Obsessions are recurrent anxious ideas, and compulsions repetitive behavior aiming to decrease this anxiety. OCD symptoms have been associated with cortical and sub-cortical dysfunctions and more precisely an hyperactivity of prefrontal cortex / basal ganglia loops. Functional neuro-imagery studies have shown a significant decrease of orbito-frontal cortex, anterior cingulate cortex, caudate nucleus and cerebellum activities after two OCD reference treatments : medication and Cognitive and Behavioral Therapy (CBT). Two groups of 20 patients are included in this study and follow a CBT for 15 sessions. They are randomised in two groups : one proposing a "reference CBT", the other associate CBT to a new psychopedagogic task developed by the investigators team. Clinical investigations and neuro-imagery data are collected at the main steps of therapies : before, during (half-therapy), at the end of therapies and 6 month later. Symptoms severity, patients and relatives quality of life are also assessed.

Conditions

Obsessive Compulsive Disorder

Keywords

Cognitive and Behavioral Therapy

Outcome Measures

Primary Outcomes (1)

• Changes in brain activity associated with different types of Cognitive Behavioral Therapy Obsessive Compulsive Disorder

  Evaluation and comparison of changes in brain activity associated with different types of Cognitive Behavioral Therapy in patients with Obsessive Compulsive Disorder

  before CBT, at half CBT (1.5 month), after CBT (3 months) and 6 six months later

Study Arms (2)

reference therapy

EXPERIMENTAL

20 OCD patients following 15 sessions of the reference CBT (Bouvard,2006)

Behavioral: Cognitive and behavioral Therapy

experimental therapy

EXPERIMENTAL

20 OCD patients following 15 sessions of reference CBT associated with a new psychopedagogic task developed by our team.

Behavioral: Cognitive and behavioral Therapy

Interventions

Cognitive and behavioral Therapy BEHAVIORAL

15 CBT sessions with a psychologist expert in OCD treatment

experimental therapy; reference therapy

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age between 18 and 65;
• Following Obsessive Compulsive Disorder criteria according to DSM IV(300.3 ;MINI 5.0.0);
• OCD severity range from 20 to 30 on the Y-Brown obsessive compulsive scale;
• Having checking symptoms;
• Understanding and accepting the study;
• Giving his written informed consent to the study.

You may not qualify if:

• Claustrophobia;
• Cerebral abnormality;
• Chronic absenteism to CBT (more than 5 missed sessions during the whole therapy).

Sponsors & Collaborators

• Institut National de la Santé Et de la Recherche Médicale, France: lead

Study Sites (1)

Pitié-Salpêtrière hospital

Paris, 75013, France

Location

Related Publications (1)

• Haynes WIA, Clair AH, Fernandez-Vidal S, Gholipour B, Morgieve M, Mallet L. Altered anatomical connections of associative and limbic cortico-basal-ganglia circuits in obsessive-compulsive disorder. Eur Psychiatry. 2018 Jun;51:1-8. doi: 10.1016/j.eurpsy.2018.01.005. Epub 2018 Mar 4.

  PMID: 29514116 BACKGROUND

MeSH Terms

Conditions

Obsessive-Compulsive Disorder

Interventions

Cognitive Behavioral Therapy

Condition Hierarchy (Ancestors)

Anxiety Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Behavior Therapy; Psychotherapy; Behavioral Disciplines and Activities

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: PARALLEL
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 29, 2010
• First Posted: April 8, 2011
• Study Start: October 1, 2009
• Primary Completion: April 1, 2012
• Study Completion: July 1, 2012
• Last Updated: September 4, 2025

Record last verified: 2012-10

Locations

FR (1)