Cardio-Respiratory Health and Indoor Pollution

NCT01329159 | Unknown

• 1 other identifier: HA indoor/pollution
• Study Type: observational
• Target: 300
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to assess in the sample of population resident in the KHUMBU valley (NEPAL):

1. 1.the respiratory function decline by means of spirometry and the respiratory health by means of questionnaire and six-minute walking distance
2. 2.the presence of markers of early atherosclerosis with ultrasound and to estimate the value of systolic pulmonary pressure in comparison with not exposed subjects.
3. 3.can accelerate the physiological respiratory function decline, usually around 15-20mL/year in healthy subjects
4. 4.induce cardiovascular impairment
5. 5.to study and analyze how the architectural features of the buildings of the village (distribution of domestic locals, natural or non natural ventilation systems, domestic activities, materials used, etc.) affect the indoor pollution from carbon monoxide, which necessarily is developed indoor during the daily life activities.

Conditions

Pulmonary Disease; Cardiovascular Disease

Keywords

High altitude; respiratory function; cardiorespiratory health; indoor pollution

Eligibility Criteria

• Age: 14 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

residents in the Kumbu Valley (Nepal)

You may qualify if:

• residents in the villages of the valley

You may not qualify if:

• under the age of 14

Sponsors & Collaborators

• Università degli Studi di Ferrara: lead
• Fondazione C.N.R./Regione Toscana "G. Monasterio", Pisa, Italy: collaborator

Study Sites (1)

Department of Clinical and Experimental Medicine- section of Respiratory Disease-University of Ferrara

Ferrara, Ferrara, 44100, Italy

Location

MeSH Terms

Conditions

Lung Diseases; Cardiovascular Diseases; Altitude Sickness; Respiratory Aspiration

Condition Hierarchy (Ancestors)

Respiratory Tract Diseases; Respiration Disorders; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Annalisa Cogo, MD

  University of Ferrara, Italy

  STUDY DIRECTOR

• Lorenza Pratali, MD

  Institute of Clinical Physiology National Council of Research, Pisa, Italy

  PRINCIPAL INVESTIGATOR

• Luca Pomidori, PhD

  Università degli Studi di Ferrara

  PRINCIPAL INVESTIGATOR

• Sanjay Nath Khanal, MD

  Kathmandu University

  PRINCIPAL INVESTIGATOR

• Enrico Duo

  Università degli Studi di Ferrara

  PRINCIPAL INVESTIGATOR

• Maria Rosa Bruno, MD

  Institute of Clinical Physiology National Council of Research, Pisa, Italy

  PRINCIPAL INVESTIGATOR

• Chan Bahadur Thapa, MD

  Tribhuvan University Institute of Medicine (Nepal)

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Annalisa Cogo, MD

CONTACT

+390532210420; cga@unife.it

Study Design

• Study Type: observational
• Observational Model: ECOLOGIC OR COMMUNITY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: April 1, 2011
• First Posted: April 5, 2011
• Study Start: April 1, 2011
• Primary Completion: April 1, 2012
• Study Completion: July 1, 2012
• Last Updated: April 5, 2011

Record last verified: 2011-03

Locations

IT (1)