NCT01324362

Brief Summary

The purpose of this study was to determine whether asthma control and reduced bronchial responsiveness could be achieved and maintained at a lower dose of inhaled corticosteroids with ADVAIR DISKUS BID or FP BID in adult and adolescent patients with persistent asthma

Trial Health

90
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
446

participants targeted

Target at P75+ for phase_4 asthma

Timeline
Completed

Started Jan 2003

Geographic Reach
4 countries

57 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2003

Completed
1.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 1, 2004

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

October 1, 2004

Completed
6.3 years until next milestone

First Submitted

Initial submission to the registry

February 3, 2011

Completed
2 months until next milestone

First Posted

Study publicly available on registry

March 29, 2011

Completed
Last Updated

September 1, 2016

Status Verified

August 1, 2016

Enrollment Period

1.8 years

First QC Date

February 3, 2011

Last Update Submit

August 31, 2016

Conditions

Keywords

FPAsthmaSontFSCBHR

Outcome Measures

Primary Outcomes (1)

  • Average ICS treatment dose over the treatment period

    Every 8 weeks through 40 weeks of treatment

Secondary Outcomes (1)

  • Pulmonary function measures

    Every 8 weeks through 40 weeks of treatment

Study Arms (2)

Fluticasone propionate

ACTIVE COMPARATOR
Drug: PlaceboDrug: FP 100mcgDrug: FP 250mcgDrug: FP 500mcg

Fluticasone propionate/salmeterol combination

ACTIVE COMPARATOR
Drug: PlaceboDrug: FSC 100/50mcgDrug: FSC 250/50mcgDrug: FSC500/50mcg

Interventions

Twice daily dosing

Also known as: FP 100mcg, FP 250mcg, FP 500mcg
Fluticasone propionate

Twice daily dosing

Fluticasone propionate

Twice daily dosing

Fluticasone propionate

Twice daily dosing

Fluticasone propionate

Twice daily dosing

Fluticasone propionate/salmeterol combination

Twice daily dosing

Fluticasone propionate/salmeterol combination

Twice daily dosing

Fluticasone propionate/salmeterol combination

Eligibility Criteria

Age12 Years+
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

  • Diagnosis of asthma
  • Controller asthma medication or medium dose ICS
  • Current or historical reversibility

You may not qualify if:

  • Life-threatening asthma
  • Asthma instability
  • Concurrent respiratory disease
  • Drug allergies
  • Respiratory tract infection
  • Systemic corticosteroid use
  • Immunosuppressive medication use
  • Postive pregnancy test
  • Tobacco use
  • Investigation medication use
  • Site affiliation

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (57)

GSK Investigational Site

Birmingham, Alabama, 35294-0012, United States

Location

GSK Investigational Site

Jasper, Alabama, 35501, United States

Location

GSK Investigational Site

Glendale, Arizona, 85304, United States

Location

GSK Investigational Site

Tucson, Arizona, 85724, United States

Location

GSK Investigational Site

Huntington Beach, California, 92647, United States

Location

GSK Investigational Site

Long Beach, California, 90806, United States

Location

GSK Investigational Site

Los Angeles, California, 90025, United States

Location

GSK Investigational Site

Los Angeles, California, 90048, United States

Location

GSK Investigational Site

Los Angeles, California, 90095-1752, United States

Location

GSK Investigational Site

Denver, Colorado, 80230, United States

Location

GSK Investigational Site

Englewood, Colorado, 80112, United States

Location

GSK Investigational Site

Fort Collins, Colorado, 80526, United States

Location

GSK Investigational Site

Pueblo, Colorado, 81008, United States

Location

GSK Investigational Site

Wheat Ridge, Colorado, 80033, United States

Location

GSK Investigational Site

Aventura, Florida, 33180, United States

Location

GSK Investigational Site

Jacksonville, Florida, 32207, United States

Location

GSK Investigational Site

Longwood, Florida, 32750, United States

Location

GSK Investigational Site

Tampa, Florida, 33609, United States

Location

GSK Investigational Site

Tampa, Florida, 33613, United States

Location

GSK Investigational Site

Coeur d'Alene, Idaho, 83814, United States

Location

GSK Investigational Site

Oak Brook, Illinois, 60523, United States

Location

GSK Investigational Site

South Bend, Indiana, 46617, United States

Location

GSK Investigational Site

Des Moines, Iowa, 50309-1426, United States

Location

GSK Investigational Site

Baltimore, Maryland, 21236, United States

Location

GSK Investigational Site

North Dartmouth, Massachusetts, 02747, United States

Location

GSK Investigational Site

Livonia, Michigan, 48152, United States

Location

GSK Investigational Site

Chesterfield, Missouri, 63017, United States

Location

GSK Investigational Site

Omaha, Nebraska, 68131, United States

Location

GSK Investigational Site

Omaha, Nebraska, 68198-2456, United States

Location

GSK Investigational Site

Mineola, New York, 11501, United States

Location

GSK Investigational Site

Charlotte, North Carolina, 28207, United States

Location

GSK Investigational Site

Wilmington, North Carolina, 28401, United States

Location

GSK Investigational Site

Winston-Salem, North Carolina, 27103, United States

Location

GSK Investigational Site

Cincinnati, Ohio, 45231, United States

Location

GSK Investigational Site

Cleveland, Ohio, 44195, United States

Location

GSK Investigational Site

Toledo, Ohio, 43614-5809, United States

Location

GSK Investigational Site

Eugene, Oregon, 97401, United States

Location

GSK Investigational Site

Lake Oswego, Oregon, 97035, United States

Location

GSK Investigational Site

Upland, Pennsylvania, 19013, United States

Location

GSK Investigational Site

Spartanburg, South Carolina, 29303, United States

Location

GSK Investigational Site

Knoxville, Tennessee, 37922, United States

Location

GSK Investigational Site

Dallas, Texas, 75231-4307, United States

Location

GSK Investigational Site

Dallas, Texas, 75231, United States

Location

GSK Investigational Site

Friendswood, Texas, 77546, United States

Location

GSK Investigational Site

Houston, Texas, 77030, United States

Location

GSK Investigational Site

Danville, Virginia, 24541, United States

Location

GSK Investigational Site

Richmond, Virginia, 23229, United States

Location

GSK Investigational Site

Bellingham, Washington, 98226, United States

Location

GSK Investigational Site

Seattle, Washington, 98105, United States

Location

GSK Investigational Site

Madison, Wisconsin, 53792, United States

Location

GSK Investigational Site

Milwaukee, Wisconsin, 53209-0996, United States

Location

GSK Investigational Site

Rio de Janeiro, Rio de Janeiro, 21941-590, Brazil

Location

GSK Investigational Site

Florianópolis, Santa Catarina, 88040970, Brazil

Location

GSK Investigational Site

São Paulo, São Paulo, Brazil

Location

GSK Investigational Site

Sofia, 1431/1000, Bulgaria

Location

GSK Investigational Site

Varna, 9010, Bulgaria

Location

GSK Investigational Site

San Juan, Puerto Rico, 00921, Puerto Rico

Location

Related Publications (1)

  • Stauffer JL, Yancey SW, Baitinger LA, Prillaman BA, Dorinsky PM. Measuring airway hyperresponsiveness: Does it add to routine measures of clinical efficacy in guiding asthma therapy? Proc Am Thorac Soc 2006;3:A213

    BACKGROUND

Related Links

MeSH Terms

Conditions

Asthma

Condition Hierarchy (Ancestors)

Bronchial DiseasesRespiratory Tract DiseasesLung Diseases, ObstructiveLung DiseasesRespiratory HypersensitivityHypersensitivity, ImmediateHypersensitivityImmune System Diseases

Study Officials

  • GSK Clinical Trials

    GlaxoSmithKline

    STUDY DIRECTOR

Study Design

Study Type
interventional
Phase
phase 4
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, INVESTIGATOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

February 3, 2011

First Posted

March 29, 2011

Study Start

January 1, 2003

Primary Completion

October 1, 2004

Study Completion

October 1, 2004

Last Updated

September 1, 2016

Record last verified: 2016-08

Data Sharing

IPD Sharing
Will share

Patient-level data for this study will be made available through www.clinicalstudydatarequest.com following the timelines and process described on this site.

Available IPD Datasets

Informed Consent Form (SAM40065)Access
Clinical Study Report (SAM40065)Access
Statistical Analysis Plan (SAM40065)Access
Annotated Case Report Form (SAM40065)Access
Dataset Specification (SAM40065)Access
Individual Participant Data Set (SAM40065)Access
Study Protocol (SAM40065)Access

Locations