NCT01319513

Brief Summary

Protein ingestion increases the rate at which the body builds new proteins in skeletal muscle (muscle protein synthesis. This study is designed to examine how the pattern of feeding affects muscle protein synthesis following resistance exercise. There is reason to believe that the large rapid increase in blood amino acid concentrations that accompanies the ingestion of a bolus of protein is important to increasing muscle protein synthesis. Thus, we hypothesize that the consumption a bolus of protein will elevate muscle protein synthesis to a greater extent than the consumption of an equivalent amount of protein that is consumed in small divided doses.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
8

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Jul 2009

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

July 1, 2009

Completed
3 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 1, 2009

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

October 1, 2009

Completed
1.5 years until next milestone

First Submitted

Initial submission to the registry

March 18, 2011

Completed
3 days until next milestone

First Posted

Study publicly available on registry

March 21, 2011

Completed
Last Updated

March 21, 2011

Status Verified

March 1, 2011

Enrollment Period

3 months

First QC Date

March 18, 2011

Last Update Submit

March 18, 2011

Conditions

Optimal Anabolic Nutrition Interventions

Outcome Measures

Primary Outcomes (1)

  • Rate of myofibrillar protein synthesis

    Rates of myofibrillar protein synthesis will be measured from muscle biopsy samples obtained from subjects participating in the study protocol.

    4 months

Secondary Outcomes (1)

  • Myocellular protein phosphorylation

    4 months

Study Arms (1)

protein feeding

EXPERIMENTAL

Participants will complete 2 trials in a cross-over fashion in which they will consume whey protein either as a single bolus or as 10 small divided doses

Other: whey protein bolusOther: whey protein pulses

Interventions

whey protein bolusOTHER

single dose of 25 g whey protein

protein feeding
whey protein pulsesOTHER

10 2.5 g pulses of whey protein

protein feeding

Eligibility Criteria

Age18 Years - 35 Years
Sexmale
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Non-obese men (BMI \<27) between the age of 18 and 35 yrs.

You may not qualify if:

  • Type II diabetes or other known diseases
  • Use of medication
  • Female
  • Other ages or BMI than indicated above
  • Resistance training \> 3X/wk

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Ivor Wynne Centre A103, McMaster University

Hamilton, Ontario, L8S 4K1, Canada

Location

Related Publications (1)

  • West DW, Burd NA, Coffey VG, Baker SK, Burke LM, Hawley JA, Moore DR, Stellingwerff T, Phillips SM. Rapid aminoacidemia enhances myofibrillar protein synthesis and anabolic intramuscular signaling responses after resistance exercise. Am J Clin Nutr. 2011 Sep;94(3):795-803. doi: 10.3945/ajcn.111.013722. Epub 2011 Jul 27.

    PMID: 21795443DERIVED

Study Officials

  • Stuart M Phillips, PhD

    McMaster University

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Intervention Model
CROSSOVER
Sponsor Type
OTHER

Study Record Dates

First Submitted

March 18, 2011

First Posted

March 21, 2011

Study Start

July 1, 2009

Primary Completion

October 1, 2009

Study Completion

October 1, 2009

Last Updated

March 21, 2011

Record last verified: 2011-03

Locations

CA(1)