Angina in Non Coronary Artery Disease
HeartQuest
Invasive Findings in Patients With Angina Equivalent Symptoms But No Coronary Artery Disease; Results From the Heart Quest Cohort Study
1 other identifier
observational
718
1 country
1
Brief Summary
Many patients undergoing coronary angiography are found to have no significant coronary artery disease (CAD) despite angina equivalent symptoms and/or electrocardiographic abnormalities suggestive of myocardial ischemia. The aim of this study is to systematically assess patients with angina equivalent symptoms despite normal coronary angiograms and to evaluate their symptoms according to a defined algorithm.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jul 1996
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
July 1, 1996
CompletedFirst Submitted
Initial submission to the registry
March 17, 2011
CompletedFirst Posted
Study publicly available on registry
March 18, 2011
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 1, 2018
CompletedStudy Completion
Last participant's last visit for all outcomes
July 1, 2018
CompletedApril 17, 2013
April 1, 2013
22 years
March 17, 2011
April 16, 2013
Conditions
Outcome Measures
Primary Outcomes (2)
Cause of angina equivalent symptoms in patients with no coronary artery disease
One day
Prognosis of patients with angina equivalent symptoms and normal coronary arteries
10 years after baseline assessment
Eligibility Criteria
All consecutive patients who had coronary angiography at the Luzerner Kantonsspital between July 1st 1996 and July 31st 2008 and who had no significant coronary stenoses (no coronary stenoses ≥ 50%) were recruited for this study.
You may qualify if:
- Coronary angiography at the Luzerner Kantonsspital between July 1st 1996 and July 31st 2008
- No significant coronary stenoses (no coronary stenoses ≥ 50%)
You may not qualify if:
- Severe valvular heart disease
- Severe congestive heart failure
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Luzerner Kantonsspital
Lucerne, Canton of Lucerne, 6000, Switzerland
Related Publications (2)
Schoenenberger AW, Adler E, Gujer S, Jamshidi P, Kobza R, Stuck AE, Resink TJ, Erne P. Prognostic value of an abnormal response to acetylcholine in patients with angina and non-obstructive coronary artery disease: Long-term follow-up of the Heart Quest cohort. Int J Cardiol. 2016 Oct 15;221:539-45. doi: 10.1016/j.ijcard.2016.07.035. Epub 2016 Jul 6.
PMID: 27414736DERIVEDSchoenenberger AW, Felber S, Gujer S, Moser A, Jamshidi P, Stuck AE, Erne P. Invasive findings in patients with angina equivalent symptoms but no coronary artery disease; results from the heart quest cohort study. Int J Cardiol. 2013 Jul 15;167(1):168-73. doi: 10.1016/j.ijcard.2011.12.053. Epub 2012 Jan 10.
PMID: 22236508DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Paul Erne, MD
Luzerner Kantonsspital
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Prof. Paul Erne
Study Record Dates
First Submitted
March 17, 2011
First Posted
March 18, 2011
Study Start
July 1, 1996
Primary Completion
July 1, 2018
Study Completion
July 1, 2018
Last Updated
April 17, 2013
Record last verified: 2013-04