The Impact of High Intensity Exercise Upon EPC Number and Function in Young Women
1 other identifier
interventional
12
1 country
1
Brief Summary
The purpose of the study is to examine the effects of different exercise intensity training programs upon blood vessel function and circulating blood cells involved in blood vessel repair in young women. The long term effects of exercise may be beneficial to cardiovascular health and it is important to understand the training methods that are the most beneficial. In particular we aim to determine if brief maximal exercise improves the function and stiffness of blood vessels and enhance blood vessel repair. Two methods of exercising are being compared, exercise bouts involving intermittent exercise and exercise completed all at once, but at a very high intensity.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Mar 2011
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 1, 2011
CompletedFirst Submitted
Initial submission to the registry
March 11, 2011
CompletedFirst Posted
Study publicly available on registry
March 14, 2011
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 1, 2012
CompletedStudy Completion
Last participant's last visit for all outcomes
November 1, 2012
CompletedMarch 14, 2011
March 1, 2011
1.5 years
March 11, 2011
March 11, 2011
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Maximal oxygen uptake
A measure of aerobic capacity determined during an incremental exercise test to volitional fatigue on an exercise ergometer.
4 weeks
Secondary Outcomes (6)
Heart rate variability
4 weeks
Endothelial progenitor cell function
4 weeks
Flow mediated dialtion
4 weeks
Arterial stiffness
4 weeks
Circulating angiogenic cell numbers
4 weeks
- +1 more secondary outcomes
Study Arms (2)
Interval maximal exercise
EXPERIMENTALInterval exercise involving repeated Wingate tests (30s durations of maximal exercise on a cycle ergometer).
Continuous maximal exercise
EXPERIMENTALContinuous exercise of maximal exertion that has been work matched to an initial bout of interval exercise of 4 x 30s of maximal exercise. This exercise is performed on a cycle ergometer.
Interventions
3 session per week of exercise on a exercise cycle ergometer. Each session involves 30s of maximal exercise followed by 4.5 min of easy cycling at 10W. This is repeated 4 times at each exercise session.
3 sessions per week of an exercise intervention involving maximal cycling until the participant has completed an amount of work equivalent to a sprint interval training session. This exercise lasts between 3 and 3.5 minutes.
Eligibility Criteria
You may qualify if:
- Young healthy females
- Between 18-25 years old
- No on medication (this includes contraceptives)
You may not qualify if:
- Medication use (including oral contraceptives)
- Amenorrhoea
- High blood pressure
- Very active (\>3 hours per week of organized physical activity)
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
University of Leeds
Leeds, West Yorkshire, LS2 9JT, United Kingdom
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Karen M Birch, BSc PhD
University of Leeds
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
March 11, 2011
First Posted
March 14, 2011
Study Start
March 1, 2011
Primary Completion
September 1, 2012
Study Completion
November 1, 2012
Last Updated
March 14, 2011
Record last verified: 2011-03