Effect of Coughing on Oxygenation in the Post Anaesthetic Care Unit

NCT01314287 | Completed DMC

• 2 other identifiers: AN10/955610/H1307/127
• Study Type: observational
• Target: 84
• Locations: 1 country
• Sites: 1

Brief Summary

General anaesthesia causes small areas of lung to collapse (referred to as atelectasis) and many strategies are used to prevent or reverse this, but these strategies only temporarily improve lung function and do not persist into the post anaesthesia care unit (PACU) where atelectasis may still be present. One possible explanation for this is that coughing occurring at the end of the anaesthesic may cause atelectasis to occur. Over 70% of patients cough when their breathing tube is removed as they emerge from the anaesthetic, and our hypothesis is that the presence of the breathing tube prevents a normal cough from occurring and may worsen atelectasis. This study will use alveolar-arterial oxygen difference (AaDO2)as a measure of how well the lungs are oxygenating the blood. This will be measured 30 minutes before the end of the anaesthetic as a control measure of the patient's lung function, and again 60 minutes after the patient has woken up, and the change compared with the amount of coughing observed as the patient emerges from the anaesthetic.

Conditions

Adverse Effect of Unspecified General Anesthetics

Keywords

Anaesthesia; pulmonary complications; Atelectasis

Outcome Measures

Primary Outcomes (1)

• Change in oxygenation before and after emergence from general anaesthesia

  Change between intraoperative and postoperative AaDO2 for each patient in relation to the amount of coughing observed on emergence from anaesthesia.

  2 hours

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

The study subjects will be adult patients undergoing routine operations which are expected to last longer than 45 minutes.

You may qualify if:

• Patients will be selected who require, as part of their normal clinical anaesthetic care, a breathing tube in their lungs and a small plastic tube (catheter) placed in an artery for monitoring and blood sampling

You may not qualify if:

• Refusal or inability to provide written, informed consent
• Respiratory disease which is severe enough to prevent the safe use of the oxygen levels required for this study
• A expectation that the patient will require their breathing to be supported artificially after the operation

Sponsors & Collaborators

• NHS Research and Development: lead
• The Leeds Teaching Hospitals NHS Trust: collaborator

Study Sites (1)

St James's University Hospital

Leeds, West Yorkshire, LS9 7TF, United Kingdom

Location

MeSH Terms

Conditions

Pulmonary Atelectasis

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases

Study Officials

• Andrew B Lumb, MB BS FRCA

  Leeds Teaching Hospitals NHS Trust

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Consultant Anaesthetist

Study Record Dates

• First Submitted: March 11, 2011
• First Posted: March 14, 2011
• Study Start: January 1, 2011
• Primary Completion: July 1, 2013
• Study Completion: July 1, 2013
• Last Updated: April 11, 2014

Record last verified: 2014-04

Locations

GB (1)