Evaluation of 4D Magnetic Resonance Angiography (K-t Blast) of Supraortic Vessels in Acute Ischemic Stroke Patients

NCT01311544 | Completed

• 2 other identifiers: 2010-A01158-31LOC/10-11
• Study Type: observational
• Target: 92
• Locations: 1 country
• Sites: 1

Brief Summary

The Magnetic Resonance angiography (MRA) of supraaortic vessels is essential for the etiologic of stroke. However, the techniques usually used provide only static evaluation (degree of stenosis, occlusion) but not dynamic. An ultra-fast 3D MRA originally developed for the cardiac imaging, k-t blast (Broad-use Linear Acquisition Speed-up Technique) could be used to review the supraaortic vessels. This MRA offers the following advantages: short acquisition time, wide spatial coverage (of the thoracic aorta to the distal encephalic arteries), 3D spatial resolution and high temporal resolution. These qualities are even more optimal with a high magnetic field (3T). The high temporal resolution is interesting because it provides to repeat a volume every eight seconds and thus to have a dynamic evaluation of vascular filling and to assess the vascular supply of the infarcted territory. This sequence is classified as a 4D MRA.

Conditions

Stroke, Acute

Outcome Measures

Primary Outcomes (1)

• Images quality for each cervical and intracranial arteries

  6 months

Secondary Outcomes (2)

• Quantification of carotid stenosis with NASCET classification

  6 months

• Study of dynamic vascular consequences of carotid stenosis

  6 months

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with acute ischemic stroke

You may qualify if:

• Men and women over 18 years
• Eligibility for intravenous thrombolytic treatment (National Institute of Neurological Disorders and Stroke criteria)
• Permanent ischemic stroke confirm with encephalic MRI (Magnetic Resonance Imaging)
• Patient able of accepting protocol information
• Patient who received information about the protocol and had not expressed its opposition to participate

You may not qualify if:

• Pacemaker
• Surgical ferromagnetic clips
• Cochlear implants
• Intraocular metallic foreign body
• Iron implants or objects likely to concentrate the Radio Frequency field
• Claustrophobia
• Known intolerance to contrast media (DOTAREM)
• Pregnant women (Beta Human Chorionic gonadotrophin performed for biological assessment of thrombolysis)
• Patient with severe kidney with Glomerular Filtration rate \< 30 ml/min
• Persons subject to major legal protection (safeguarding justice, guardianship, trusteeship), persons deprived of liberty

Sponsors & Collaborators

• Rennes University Hospital: lead

Study Sites (1)

Rennes University Hospital

Rennes, Brittany Region, 35033, France

Location

MeSH Terms

Conditions

Stroke

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Study Officials

• jean-yves gauvrit

  Rennes University Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 7, 2011
• First Posted: March 9, 2011
• Study Start: March 1, 2011
• Last Updated: May 16, 2012

Record last verified: 2012-05

Locations

FR (1)