NCT01310283

Brief Summary

The goal of this study is to address the effectiveness of a modified cavity prevention protocol for 5-9 year-old children which emphasizes better diet modification, more frequent professional fluoride applications, and xylitol product usage based on individual risk status in a 1-year randomized controlled clinical trial in the University of California, San Francisco (UCSF) Tenderloin Community Pediatric Dental Clinic. The investigators hypothesize that the regimen will help to reduce new cavities in children who are at risk for dental cavities.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
120

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Apr 2010

Typical duration for not_applicable

Geographic Reach
1 country

2 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 1, 2010

Completed
11 months until next milestone

First Submitted

Initial submission to the registry

March 4, 2011

Completed
4 days until next milestone

First Posted

Study publicly available on registry

March 8, 2011

Completed
1.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 1, 2012

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

May 1, 2012

Completed
Last Updated

November 14, 2012

Status Verified

November 1, 2012

Enrollment Period

2.1 years

First QC Date

March 4, 2011

Last Update Submit

November 9, 2012

Conditions

Keywords

dental carieschildrenmutans streptococcilactobacillicariogenic bacteria

Outcome Measures

Primary Outcomes (1)

  • new decayed surfaces

    1 year

Secondary Outcomes (1)

  • cariogenic bacteria levels

    6 month and 1 year

Study Arms (1)

control group

NO INTERVENTION

Conventional pediatric dental care.

Other: xylitol mints and fluoride varnish

Interventions

Subjects in the intervention group will receive additional diet, oral hygiene handouts, more frequent professional fluoride application, and xylitol mints based on their caries risk levels.

control group

Eligibility Criteria

Age5 Years - 9 Years
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17)

You may qualify if:

  • Patients of record at the UCSF Pediatric Dental Clinic, or the UCSF Tenderloin Community Pediatric Dental Clinic, and must be:
  • Patients of record at the Tenderloin community and UCSF pediatric dental clinics
  • years old
  • \. Be able to give informed assent, consent and answer questionnaires in English, Spanish or Chinese by parents or guardian 4. Be unlikely to move from the area during the study period 5. Be willing to participate regardless of group assignment and comply with all study procedures

You may not qualify if:

  • Persons with:
  • Prolonged antibiotic use in the past three months.
  • Dental needs outside of the community pediatric clinics, such as care provided in specialty clinics

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (2)

Pediatric Dental Clinic at UCSF, School of Dentistry and UCSF Pediatric Dentistry Clinica at the Tenderloin Community School

San Francisco, California, 94143, United States

Location

The Pediatric Dentistry Clinic at UCSF and Tenderloin Community Elementary School

San Francisco, California, 94143, United States

Location

MeSH Terms

Conditions

Dental Caries

Condition Hierarchy (Ancestors)

Tooth DemineralizationTooth DiseasesStomatognathic Diseases

Study Officials

  • Ling Zhan, DDS, PhD

    University of California, San Francisco

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Asisstant professor in residence

Study Record Dates

First Submitted

March 4, 2011

First Posted

March 8, 2011

Study Start

April 1, 2010

Primary Completion

May 1, 2012

Study Completion

May 1, 2012

Last Updated

November 14, 2012

Record last verified: 2012-11

Locations