Effect of Remote Ischemic Preconditioning on Lung Injury After Pulmonary Resection
1 other identifier
interventional
108
1 country
1
Brief Summary
The purpose of this study is to determine whether ischemic preconditioning reduces lung injury in patients undergoing pulmonary resection.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Feb 2011
Typical duration for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
February 1, 2011
CompletedFirst Submitted
Initial submission to the registry
March 1, 2011
CompletedFirst Posted
Study publicly available on registry
March 2, 2011
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2013
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2013
CompletedDecember 12, 2013
December 1, 2013
2.3 years
March 1, 2011
December 11, 2013
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Limb remote ischemic preconditioning has effective protection of lung injury in patients undergoing pulmonary lobectomy
PaO2/FiO2 in the limb RIPC group was significantly higher than that in the control group at 30 and 60 min after OLV, 30 min and 6 h after operation (all P\<0.05)
June,2013
Secondary Outcomes (2)
Cs and Cd
June,2013
IL-6 and TNF-α
June,2013
Study Arms (2)
preconditioning
EXPERIMENTALAdult patients undergoing elective pulmonary lobectomy were received a remote ischemic preconditioning group after induction of anaesthesia.
conventional
NO INTERVENTIONAdult patients undergoing pulmonary lobectomy were received no treatment after induction of anaesthesia.
Interventions
Remote ischaemic preconditioning consisted of three 5-min cycles of right upper limb ischaemia, induced by an automated cuff-inflator placed on the upper arm and inflated to 200 mm Hg, with an intervening 5 min of reperfusion during which the cuff was deflated.
Eligibility Criteria
You may qualify if:
- Clinical diagnosis of pulmonary carcinoma
- Must be received pulmonary lobectomy
You may not qualify if:
- Cardiac disease categorized as NYHA classes II-IV
- Preoperative severe impairment of respiratory function (arterial oxygen tension (PaO2) \<60 mmHg or FEV1\<50% predicted),
- Pre-existing coagulopathy or thrombocytopenia
- Prior receipt of chemotherapy or radiation therapy or immunotherapy
- Systemic or local active infections (either clinically defined or suggested by evidence such as elevated C-reactive protein levels, leukocytosis, or a body temperature\>38℃)
- Peripheral vascular disease affecting the upper limbs
- Administration of vitamins, nonsteroidal anti-inflammatory agent or corticosteroid within 3 months.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Cai Lilead
Study Sites (1)
Departmeng of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University
Guangzhou, Guangdong, 510080, China
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Xuan Ke Liu, Ph.d
Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR INVESTIGATOR
- PI Title
- Department of Anesthesiology, First Affiliated Hospital, Sun Yat-Sen University
Study Record Dates
First Submitted
March 1, 2011
First Posted
March 2, 2011
Study Start
February 1, 2011
Primary Completion
June 1, 2013
Study Completion
June 1, 2013
Last Updated
December 12, 2013
Record last verified: 2013-12