Dietary Polyphenols and Lipid Oxidation

NCT01302639 | Completed

• 1 other identifier: MEC 10-03-032.7
• Study Type: interventional
• Target: 18
• Locations: 1 country
• Sites: 1

Brief Summary

There are strong indications that (combinations of) polyphenols may be attractive candidates in the prevention of the metabolic syndrome and diabetes through modulation of pathways of fatty acid metabolism and mitochondrial function. We hypothesize that the combination of specific polyphenols, with partly distinct mechanisms of action, may have physiologically significant effects on fat oxidation through additive or synergistic effects, thereby improving body composition, insulin sensitivity and preventing type 2 diabetes. The following objective will be addressed in the current study: (1) to test short term (3 day) effects of combinations of polyphenols (supplements of EGCG either in combination with resveratrol or with resveratrol and genistein) to affect systemic lipolysis and fat oxidation during overnight fasted conditions and after ingestion of a high fat meal in overweight subjects

Conditions

Obesity, Insulin Sensitivity, Type 2 Diabetes Mellitus

Outcome Measures

Primary Outcomes (1)

• postprandial fat oxidation

  3 day supplementation of different combinations of polyphenols in a randomised crossover design in healthy overweight volunteers. At the end of each supplementation period, postprandial fat oxidation is measured

  3 days

Study Arms (3)

EGCG and resveratrol

EXPERIMENTAL

Dietary Supplement: Comparison of different combinations of polyphenols with respect to effects on fat oxidation

EGCG, resveratrol and genistein

EXPERIMENTAL

Dietary Supplement: Comparison of different combinations of polyphenols with respect to effects on fat oxidation

placebo

PLACEBO COMPARATOR

Dietary Supplement: Comparison of different combinations of polyphenols with respect to effects on fat oxidation

Interventions

Comparison of different combinations of polyphenols with respect to effects on fat oxidation DIETARY_SUPPLEMENT

EGCG, resveratol and genistein

EGCG and resveratrol; EGCG, resveratrol and genistein; placebo

Eligibility Criteria

• Age: 30 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may not qualify if:

• women lactating, pregnant or (post)menopausal, regular smokers, people with intensive fitness training, eg. athletes (≥ 3 per week ≥ 1 hour training), habitual consumption of green tea (more than 1 cup per day) or products containing green tea extract, total caffeine consumption \> 300 mg/day, alcohol intake \>20 g/day, any dietary vitamins or dietary supplements, diabetes mellitus (defined as FPG ≥ 7.0 mmol/l and/or 2hPG ≥ 11.1 mmol/l); serious pulmonary, cardiovascular, hepatic or renal disease : history of cardiovascular disease, all other relevant medical disorders that potentially interfere with this trial, current use of medication interfering with study intervention or interfering with study endpoints/hypotheses.

Sponsors & Collaborators

• Maastricht University Medical Center: lead
• Alpro Foundation: collaborator

Study Sites (1)

Maastricht University

Maastricht, 6200 MD, Netherlands

Location

Related Publications (1)

• Most J, Goossens GH, Jocken JW, Blaak EE. Short-term supplementation with a specific combination of dietary polyphenols increases energy expenditure and alters substrate metabolism in overweight subjects. Int J Obes (Lond). 2014 May;38(5):698-706. doi: 10.1038/ijo.2013.231. Epub 2013 Dec 9.

  PMID: 24317366 DERIVED

MeSH Terms

Conditions

Obesity; Insulin Resistance; Diabetes Mellitus, Type 2

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Diabetes Mellitus; Endocrine System Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 22, 2011
• First Posted: February 24, 2011
• Study Start: February 1, 2011
• Primary Completion: October 1, 2013
• Study Completion: November 1, 2013
• Last Updated: September 9, 2014

Record last verified: 2014-09

Locations

NL (1)