Imaging of Cognition, Learning, and Memory in Aging
2 other identifiers
observational
294
1 country
1
Brief Summary
This investigation is designed to study how the brain functions when it is performing explicit memory tasks, and furthermore how the brain systems supporting performance on these tests change as a function of aging. Implicit memory tasks may be distinguished from explicit memory tests in that explicit memory characterizes the directed or intentional recollection of previously learned information or events. In contrast, implicit (or nonconscious) memory is expressed in the facilitation of performance on some task or judgment on a stimulus owing to a prior presentation of that stimulus, without any necessary conscious awareness of the prior presentation. The investigators propose to use functional Magnetic resonance Imaging (fMRI) to measure brain activity during the performance of carefully designed explicit memory tasks. Comparison of brain activity during the different test conditions will provide information about the brain areas that are involved in mediating specific aspects of performance. Both older and younger individuals will be tested in order to understand age related changes in the brain activity. In order to examine the interactions between participants' differential levels of amyloid burden and their performance on cognitive tasks and fMRI neural activation, the investigators also propose PET imaging of older participants.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Mar 2011
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
February 14, 2011
CompletedFirst Posted
Study publicly available on registry
February 16, 2011
CompletedStudy Start
First participant enrolled
March 1, 2011
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 1, 2017
CompletedStudy Completion
Last participant's last visit for all outcomes
October 1, 2017
CompletedNovember 1, 2017
October 1, 2017
6.6 years
February 14, 2011
October 30, 2017
Conditions
Outcome Measures
Primary Outcomes (1)
Cognition as measured with cognitive evaluations
We will assess the relationship between the presence of amyloid and cognition as measured with standard cognitive and neuropsychological tests
cross sectional
Study Arms (2)
Participants aged 60-70
Participants age 60-70 will receive Florbetaben PET tracer to identify presence of amyloid burden.
Participants aged 20-30
Younger participants will not undergo PET scanning that will be studied with other methods.
Interventions
This is a purely observational study. Results of the Florbetaben PET scan will be correlated with other observations.
Eligibility Criteria
Subjects will be recruited from ads placed in local newspapers and notices posted in the vicinity of Columbia University, the Columbia Presbyterian Medical Center, and in local senior centers that provide written consent for notice placement. We will also utilize a market mailing approach. Letters will be sent to appropriately aged potential subjects randomly selected from commercial lists. Additional elderly subjects will be recruited from the Sergievsky Joint Database. Informed consent will be elicited from all subjects.
You may qualify if:
- Aged 20-30 or 60-70
- Residing near Columbia University Medical Center
- Must be willing and able to participate
You may not qualify if:
- Have a contraindication to PET (e.g, metallic implants, pacemaker, claustrophobia, or cannot lie flat for one hour)
- Pregnancy
- Lactating Women
- Current, past, or anticipated exposure to radiation
- Significant active physical illness
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Yaakov Sternlead
- National Institute on Aging (NIA)collaborator
Study Sites (1)
Columbia University Medical Center
New York, New York, 10032, United States
Related Publications (2)
Oh H, Steffener J, Razlighi QR, Habeck C, Stern Y. beta-Amyloid Deposition Is Associated with Decreased Right Prefrontal Activation during Task Switching among Cognitively Normal Elderly. J Neurosci. 2016 Feb 10;36(6):1962-70. doi: 10.1523/JNEUROSCI.3266-15.2016.
PMID: 26865619BACKGROUNDOh H, Steffener J, Razlighi QR, Habeck C, Liu D, Gazes Y, Janicki S, Stern Y. Abeta-related hyperactivation in frontoparietal control regions in cognitively normal elderly. Neurobiol Aging. 2015 Dec;36(12):3247-3254. doi: 10.1016/j.neurobiolaging.2015.08.016. Epub 2015 Aug 24.
PMID: 26382734BACKGROUND
Biospecimen
Whole blood (frozen)
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Yaakov Stern, PhD
Columbia University
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR INVESTIGATOR
- PI Title
- Professor of Neuropsychology
Study Record Dates
First Submitted
February 14, 2011
First Posted
February 16, 2011
Study Start
March 1, 2011
Primary Completion
October 1, 2017
Study Completion
October 1, 2017
Last Updated
November 1, 2017
Record last verified: 2017-10
Data Sharing
- IPD Sharing
- Will share
- Time Frame
- Study data will be available within 1 year
- Access Criteria
- We will be sharing de-identified data with a consortium that is aggregating studies that have employed amyloid PET tracers
De-identified data could be shared based on NIH regulations