Study Evaluating Management of Patients With Community-Acquired Pneumonia (CAP) or Complicated Skin Infections
REACH
Observational Study to Assess Clinical Management Patterns in Patients With Hospitalised Community-Acquired Pneumonia (CAP) or Complicated Skin and Skin Structure Infections (cSSSI)
1 other identifier
observational
4,035
10 countries
163
Brief Summary
This study will collect real-life data from patients with community acquired pneumonia (CAP) OR complicated skin and skin structure infections (cSSSI) to assess the burden of the disease, review the treatment pathways, evaluate how health resources are used and identify any areas of unmet medical needs. The aim of the study is to compare how patients who are admitted to hospital with CAP or cSSSI are managed across Europe. This will be done by collecting data to understand the patient and disease characteristics, current practice of treatment, and outcomes for the patient. Overall 4000 patients will be recruited from 10 European countries.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Mar 2011
Shorter than P25 for all trials
163 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
February 6, 2011
CompletedFirst Posted
Study publicly available on registry
February 10, 2011
CompletedStudy Start
First participant enrolled
March 1, 2011
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2011
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2011
CompletedSeptember 7, 2012
September 1, 2012
3 months
February 6, 2011
September 6, 2012
Conditions
Keywords
Outcome Measures
Primary Outcomes (5)
Number of patients with infection resolution reaching clinical stability, as a measure of effectiveness
Retrospective. Outcome measures will be determined in patients hospitalized between 2010-12-01 and 2011-01-31, from the date of hospitalization, up to the date of hospital discharge (2011-02-28 at the latest).
Number of patients reaching clinical stability, as a measure of effectiveness
Retrospective. Outcome measures will be determined in patients hospitalized between 2010-12-01 and 2011-01-31, from the date of hospitalization, up to the date of hospital discharge (2011-02-28 at the latest).
Number of patients death, as a measure of clinical failure
Retrospective. Outcome measures will be determined in patients hospitalized between 2010-12-01 and 2011-01-31, from the date of hospitalization, up to the date of hospital discharge (2011-02-28 at the latest).
Number of patients with infection recurrence, as a measure of clinical failure
Retrospective. Outcome measures will be determined in patients hospitalized between 2010-12-01 and 2011-01-31, from the date of hospitalization, up to the date of hospital discharge (2011-02-28 at the latest).
Number of patients requiring change in antibiotic, as a measure of clinical failure
Retrospective. Outcome measures will be determined in patients hospitalized between 2010-12-01 and 2011-01-31, from the date of hospitalization, up to the date of hospital discharge (2011-02-28 at the latest).
Secondary Outcomes (6)
Number of patients hospitalized with CAP or cSSSI, in each type of hospital and department, as a descriptive measure of burden of disease, and patient flow.
Retrospective. Outcome measures will be determined in patients hospitalized between 2010-12-01 and 2011-01-31.
Number and type of diagnostic tests, as measure of use of resources
Retrospective. Outcome measures will be determined in patients hospitalized between 2010-12-01 and 2011-01-31, from the date of hospitalization, up to the date of hospital discharge (2011-02-28 at the latest).
Type of medications used, as measure of use of resources
Retrospective. Outcome measures will be determined in patients hospitalized between 2010-12-01 and 2011-01-31, from the date of hospitalization, up to the date of hospital discharge (2011-02-28 at the latest).
Duration of hospitalisation, as measure of use of resources
Retrospective. Outcome measures will be determined in patients hospitalized between 2010-12-01 and 2011-01-31, from the date of hospitalization, up to the date of hospital discharge (2011-02-28 at the latest).
Number of patients requiring ICU / isolation / mechanical ventilation / complications, as measure of use of resources
Retrospective. Outcome measures will be determined in patients hospitalized between 2010-12-01 and 2011-01-31, from the date of hospitalization, up to the date of hospital discharge (2011-02-28 at the latest).
- +1 more secondary outcomes
Study Arms (1)
1
Eligibility Criteria
Patients over 18, diagnosed with community acquired pneumonia or complicated skin and skin structure infection hospitalised between 2010-12-01 and 2011-01-31.
You may qualify if:
- Patients hospitalised with CAP or cSSSI
- CAP: Radiographically-confirmed bacterial pneumonia AND Requiring treatment with IV antimicrobials as start-up therapy
- cSSSI: Affecting deeper soft tissue and/or requiring significant surgical intervention or developing an abcess/ulcer/cellulitis in a lower limb AND Having at least two local signs and one systemic sign of cSSS AND Treatment with antimicrobials
You may not qualify if:
- Patients already participating in clinical trials or any other interventional study.
- CAP: CAP suitable for outpatient therapy with an oral antimicrobial agent.
- cSSSI: Uncomplicated SSSI. Skin and skin-structure infections with a high cure rate after surgical incision alone or after aggressive local skin care.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- AstraZenecalead
Study Sites (163)
Research Site
Aalst, Belgium
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Bonheiden, Belgium
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Brussels, Belgium
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Charleroi, Belgium
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Dinant, Belgium
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Edegem, Belgium
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Godinne, Belgium
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Hasselt, Belgium
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Liège, Belgium
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Mons, Belgium
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Montigny-le-Tilleul, Belgium
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Alençon, France
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Amboise, France
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Amiens, France
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Bayonne, France
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Bergerac, France
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Briançon, France
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Brive-la-Gaillarde, France
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Cahors, France
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Cayenne, France
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Chambéry, France
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Chauny, France
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Cognac, France
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Colombes, France
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Compiègne, France
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Creil, France
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Decazeville, France
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Denain, France
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Dunkirk, France
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Eaubonne, France
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Évreux, France
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Fécamp, France
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Hyères, France
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La Tronche, France
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Lagny-sur-Marne, France
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Le Chesnay, France
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Le Coudray, France
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Le Mans, France
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Lens, France
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Libourne, France
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Lille, France
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Marseille, France
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Metz, France
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Montdidier, France
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Paris, France
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Pau, France
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Pontarlier, France
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Rethel, France
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Saint-Aubin-lès-Elbeuf, France
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Saint-Brieuc, France
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Saint-Dié, France
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Saint-Hilaire-du-Harcouët, France
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Saint-Priest-en-Jarez, France
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Saint-Quentin, France
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Saintes, France
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Salon-de-Provence, France
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Strasbourg, France
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Tarbes, France
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Toul, France
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Tulle, France
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Vendôme, France
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Vesoul, France
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Ulm, Baden-Wurttemberg, Germany
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Aachen, North Rhine-Westphalia, Germany
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Bochum, North Rhine-Westphalia, Germany
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Dortmund, North Rhine-Westphalia, Germany
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Paderborn, North Rhine-Westphalia, Germany
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Kiel, Schleswig-Holstein, Germany
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Lübeck, Schleswig-Holstein, Germany
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Berlin, State of Berlin, Germany
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Alexandroupoli, Greece
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Athens, Greece
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Crete, Greece
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Larissa, Greece
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Piraeus, Greece
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Thessaloniki, Greece
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S.G. Rotondo, Foggia, Italy
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Rozzano, Milano, Italy
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Pietra Ligure, Savona, Italy
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Borgo Roma, Verona, Italy
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Bologna, Italy
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Brescia, Italy
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Catania, Italy
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Catanzaro, Italy
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Chieti, Italy
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Cuneo, Italy
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Enna, Italy
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Florence, Italy
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Genova, Italy
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Latina, Italy
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Lodi, Italy
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Milan, Italy
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Modena, Italy
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Napoli, Italy
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Padua, Italy
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Palermo, Italy
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Pavia, Italy
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Pesaro, Italy
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Pisa, Italy
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Reggio Calabria, Italy
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Roma, Italy
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Sassari, Italy
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Savona, Italy
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Siena, Italy
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Torino, Italy
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Varese, Italy
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Harderwijk, Gelderland, Netherlands
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Breda, North Brabant, Netherlands
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Nieuwegein, Utrecht, Netherlands
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Breda, Netherlands
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Groningen, Netherlands
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Leiden, Netherlands
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Nijmegen, Netherlands
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Utrecht, Netherlands
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Zoetermeer, Netherlands
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Amadora, Portugal
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Lisbon, Portugal
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Penafiel, Portugal
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Portimão, Portugal
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Torres Novas, Portugal
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Viana do Castelo, Portugal
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Vila Nova de Gaia, Portugal
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Terrassa, Barcelona, Spain
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Santiago de Compostela, Coruna, Spain
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Vigo, Pontevedra, Spain
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A Coruña, Spain
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Alicante, Spain
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Barcelona, Spain
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Córdoba, Spain
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Madrid, Spain
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Málaga, Spain
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Oviedo, Spain
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Palma de Mallorca, Spain
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Santander, Spain
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Seville, Spain
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Valencia, Spain
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Bolu, Abant, Turkey (Türkiye)
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Izmir, Balova, Turkey (Türkiye)
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Ankara, Be?evler, Turkey (Türkiye)
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Ankara, Besevler, Turkey (Türkiye)
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Ankara, Bilkent, Turkey (Türkiye)
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Izmir, Bornova, Turkey (Türkiye)
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?zmir, Bozyaka, Turkey (Türkiye)
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Istanbul, Capa, Turkey (Türkiye)
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Istanbul, Cerrahpasa, Turkey (Türkiye)
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Ankara, Dskapi, Turkey (Türkiye)
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Antalya, Dumlupinar Mevkii, Turkey (Türkiye)
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?stanbul, Kartal, Turkey (Türkiye)
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Istanbul, Mraniye, Turkey (Türkiye)
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Bursa, Nilfer, Turkey (Türkiye)
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Samsun, Ondokuz Mayıs, Turkey (Türkiye)
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Eskiehir, Osmangazi, Turkey (Türkiye)
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Ankara, S?hhiye, Turkey (Türkiye)
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Ankara, Sihhiye, Turkey (Türkiye)
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Aintree, United Kingdom
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Blackpool, United Kingdom
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Edinburgh, United Kingdom
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Hull, United Kingdom
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Leicester, United Kingdom
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Liverpool, United Kingdom
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Middlesbrough, United Kingdom
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Newcastle, United Kingdom
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Winchester, United Kingdom
Related Publications (3)
Garau J, Blasi F, Medina J, McBride K, Ostermann H; REACH study group. Early response to antibiotic treatment in European patients hospitalized with complicated skin and soft tissue infections: analysis of the REACH study. BMC Infect Dis. 2015 Feb 19;15:78. doi: 10.1186/s12879-015-0822-2.
PMID: 25879713DERIVEDBlasi F, Ostermann H, Racketa J, Medina J, McBride K, Garau J; REACH study group. Early versus later response to treatment in patients with community-acquired pneumonia: analysis of the REACH study. Respir Res. 2014 Jan 22;15(1):6. doi: 10.1186/1465-9921-15-6.
PMID: 24450444DERIVEDBlasi F, Garau J, Medina J, Avila M, McBride K, Ostermann H; REACH study group. Current management of patients hospitalized with community-acquired pneumonia across Europe: outcomes from REACH. Respir Res. 2013 Apr 15;14(1):44. doi: 10.1186/1465-9921-14-44.
PMID: 23586347DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
February 6, 2011
First Posted
February 10, 2011
Study Start
March 1, 2011
Primary Completion
June 1, 2011
Study Completion
June 1, 2011
Last Updated
September 7, 2012
Record last verified: 2012-09