Loading search results
VTICU
Application of Vibration Therapy as a Measure of Muscle Activation in ICU Patients and Its Effect on Hemodynamics, Intracranial Pressure as Well as Energy Metabolism
Sponsor study identifier
interventional
20
1 country
1
Study Start
February 2011
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
January 2012
Actual (reported)Study Completion
May 2012
Actual (reported)Vibration therapy is used for different indications in rehabilitation and sports medicine. So far, vibration therapy has not been investigated within the ICU setting. The investigators created this setting to show safety and applicability of vibration therapy in ICU patients. 30 patients will be stimulated by vibration therapy on two separate days during their ICU stay. Three collectives of equal size will be observed: One with patients on mechanical ventilation without signs of infection or suspected intracranial pressure problems, a second one with patients on mechanical ventilation in addition to signs of systemic inflammation but absence of suspected intracranial pressure problems, and a third one with patients on mechanical ventilation, signs of systemic inflammation in addition to presence of controlled intracranial pressure problems. Typical parameters of hemodynamic status, intracranial pressure and energy metabolism will be recorded for a defined period of time before, during and after vibration therapy itself. Vibration therapy will be combined with protocol based physiotherapy. Our aim is to show the effects of vibration therapy in ICU patients and its safe applicability. ADDITION 06th of May 2011: Additionally we will perform euglycaemic hyperinsulinemic clamp and intervention on one day of ICU stay in 20 patients. Under clamp conditions we will perform a vibration therapy (ProMedVi Vibrosphere™) on patients' legs. On top we will perform electrical muscle stimulation (schwa-medico, MUSKELaktiv™) on one ventral upper leg, randomized chosen. Measuring the local skeletal muscle metabolism will be done by microdialysis in Vastus lateralis on both sides - comparing vibration therapy and vibration therapy combined with electrical muscle stimulation.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
May 2012
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
January 28, 2011
Actual (reported)January 31, 2011
Actual (reported)February 2011
Date type not reportedThis date has not been verified as actual or estimated.
January 2012
Actual (reported)May 2012
Actual (reported)Change of vital parameters as a measure of hemodynamic stability to show safety and tolerability
Changes in heart rate, arterial blood pressure, saturation of peripheral pulse oximetry, intracranial pressure, mechanical ventilation parameters, electrolytes, blood sugar and lactate levels, blood pH, PICCO-parameters, body temperature as well as pO2 und pCO2 partial pressure.
Continuous record for 90 minutes - within 4 blood samples - vibration therapy compared to baseline
Change of vital parameters as a measure of hemodynamic stability to show safety and tolerability.
Continuous record for 90 minutes - within 4 blood samples - vibration therapy compared to baseline
Change in peripheral energy metabolism and hormonal state as a measure of muscle activation and systemic inflammatory reaction induced by vibration therapy.
vibration therapy
Electrical muscle stimulation
Charite University, Berlin, Germany
Berlin, 13353, Germany
Wollersheim T, Haas K, Wolf S, Mai K, Spies C, Steinhagen-Thiessen E, Wernecke KD, Spranger J, Weber-Carstens S. Whole-body vibration to prevent intensive care unit-acquired weakness: safety, feasibility, and metabolic response. Crit Care. 2017 Jan 9;21(1):9. doi: 10.1186/s13054-016-1576-y.
Steffen Weber-Carstens, MD
Dept. of Anesthesiology and Intensive Care Medicine, Charite University, Berlin, Germany
20 participants (actual enrollment reported by the registry).
First Submitted
January 28, 2011
First Posted
January 31, 2011
Study Start
February 2011
Date type not reportedThis date has not been verified as actual or estimated.
Continuous record for 90 minutes - within 4 blood samples - vibration therapy compared to baseline
Change in peripheral energy metabolism and hormonal state as measure of muscle activation and systemic inflammatory reaction induced by vibration therapy
Continuous record for 90 minutes - within 4 blood samples - vibration therapy compared to baseline
Change in systemic and local energy metabolism as measure of muscle activation by vibration therapy and electrical muscle stimulation
Continuous record for app. 10 hours - therapy compared to baseline
vibration therapy
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Contact the study team to confirm eligibility.
Primary Completion
January 2012
Actual (reported)Study Completion
May 2012
Actual (reported)Last Updated
February 9, 2017
Record last verified: 2017-02
Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.
Source: ClinicalTrials.gov.
JSON downloads include source attribution and retrieval details alongside the unchanged original record or the separately normalized values.
Source retrieved: