Endometrial Biopsy Protocol for In Vitro Fertilization (IVF)
Comparing Timing and Number of Endometrial Biopsies in IVF Treatment and Identifying Biochemical Markers to Predict Endometrial Receptivity
1 other identifier
interventional
200
1 country
2
Brief Summary
Endometrial biopsy has been shown to improve IVF pregnancy and live birth rates. The optimal time of performing the biopsy is yet to be established. In this study, the investigators will compare different temporal timing of the biopsies with regards to the menstrual cycle and their affect on the success rates of the treatment.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2011
CompletedFirst Submitted
Initial submission to the registry
January 18, 2011
CompletedFirst Posted
Study publicly available on registry
January 19, 2011
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 1, 2013
CompletedJanuary 26, 2011
December 1, 2010
2 years
January 18, 2011
January 25, 2011
Conditions
Outcome Measures
Primary Outcomes (1)
pregnancy rates
2 years
Secondary Outcomes (1)
live birth rates
3 years
Study Arms (4)
no treatment
NO INTERVENTIONone biopsy, proliferative phase
EXPERIMENTALone biopsy, secretory phase
EXPERIMENTALtwo biopsies
EXPERIMENTALInterventions
performing office endometrial biopsy with a disposable sterile catheter
Eligibility Criteria
You may qualify if:
- normal menstrual cycle
- between 1-6 previous failed IVF cycles
- normal hormonal profile
You may not qualify if:
- intrauterine procedure in last 3 months
- hydrosalpinx
- intrauterine lesion /malformation
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (2)
Kaplan Medical Center, IVF Unit
Rehovot, Israel
Weizmann Institute of Science
Rehovot, Israel
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
January 18, 2011
First Posted
January 19, 2011
Study Start
January 1, 2011
Primary Completion
January 1, 2013
Last Updated
January 26, 2011
Record last verified: 2010-12