Observe Abnormal Potential From the Offending Vessel to the Facial Muscles of HFS Patients
Observation of the Abnormal Potential From the Offending Vessel to the Facial Muscles of Hemifacial Spasm Patients
1 other identifier
observational
20
1 country
1
Brief Summary
The pathophysiologic basis of hemifacial spasm is cross-transmission between different branches of the facial nerve. The hypothesis is that the cross-transmission is mediated by the sympathetic nerve fibers on the surface of the offending artery. The abnormal potential from the offending vessel to the facial muscles will be detected on hemifacial spasm patients, so as to determine if the sympathetic nerve fibers take part in the circuit of cross-transmission.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for all trials
Started Jan 2011
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2011
CompletedFirst Submitted
Initial submission to the registry
January 5, 2011
CompletedFirst Posted
Study publicly available on registry
January 7, 2011
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2011
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2011
CompletedJuly 25, 2011
July 1, 2011
11 months
January 5, 2011
July 22, 2011
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Abnormal Potential From the Offending Vessel to the Facial Muscles
up to 4 months
Secondary Outcomes (1)
Latency from the root entry zone of facial nerve to the facial muscles
up to 4 months
Eligibility Criteria
This study will enroll 20 cases of hemifacial spasm patients who want to undergo microvascular decompression.
You may qualify if:
- the age of 18-65 years old;
- with typical hemifacial spasm symptoms;
- with typical abnormal muscle response;
- preoperative magnetic resonance imaging revealed obvious paraneural artery;
- with informed consent.
You may not qualify if:
- pregnant or lactating women;
- accompanied by other serious diseases, including liver, kidney, cardiovascular diseases;
- accompanied by mental illness or severe neurosis;
- unable to express the subjective symptoms.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
XinHua Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine
Shanghai, Shanghai Municipality, 200092, China
Related Publications (1)
Moller AR, Jannetta PJ. On the origin of synkinesis in hemifacial spasm: results of intracranial recordings. J Neurosurg. 1984 Sep;61(3):569-76. doi: 10.3171/jns.1984.61.3.0569.
PMID: 6086858BACKGROUND
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Xuesheng Zheng, M.D.
Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Study Design
- Study Type
- observational
- Observational Model
- CASE ONLY
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
January 5, 2011
First Posted
January 7, 2011
Study Start
January 1, 2011
Primary Completion
December 1, 2011
Study Completion
December 1, 2011
Last Updated
July 25, 2011
Record last verified: 2011-07