The Effect of Volatile Anesthetics Sevoflurane and Desflurane on Liver, Renal and Cardiovascular Systems During Liver Surgery
1 other identifier
interventional
40
1 country
1
Brief Summary
The aim of the study is to investigate the effect of sevoflurane and desflurane on hepatic function after ischemic/reperfusion injury and the sequence influence on renal and cardiovascular systems.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for phase_4
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
December 1, 2010
CompletedFirst Submitted
Initial submission to the registry
December 28, 2010
CompletedFirst Posted
Study publicly available on registry
December 29, 2010
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2011
CompletedDecember 29, 2010
December 1, 2010
1 year
December 28, 2010
December 28, 2010
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Oxidotic stress after hepatectomy.
Perioperative liver and renal biopsies and follow up with liver renal function tests plus intraoperative and postoperative cardiovascular monitoring
5 d postop.
Secondary Outcomes (1)
Liver and renal dysfunction
5 d
Study Arms (2)
Sevoflurane
ACTIVE COMPARATOR1MAC intraoperatively
desflurane
ACTIVE COMPARATOR1 MAC intraoperatively
Interventions
Eligibility Criteria
You may qualify if:
- Patients undergoing liver surgery
You may not qualify if:
- ASA IV, Cardiovascular diseases
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Aretaieio Hospital
Athens, Attica, 115 28, Greece
Study Officials
- PRINCIPAL INVESTIGATOR
Georgios P Fragulidis, MD
Areataieio Hospital
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- phase 4
- Allocation
- RANDOMIZED
- Masking
- QUADRUPLE
- Who Masked
- PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- BASIC SCIENCE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
December 28, 2010
First Posted
December 29, 2010
Study Start
December 1, 2010
Primary Completion
December 1, 2011
Last Updated
December 29, 2010
Record last verified: 2010-12