NCT01266343

Brief Summary

The investigators wanted to reported the results of immediate anterior chamber paracentesis (ACP), compared to Mannitol infusion, in patients with acute primary angle-closure glaucoma (PACG). In this study, the investigators first divided patients into three sub-groups according to their initial intraocular pressure (IOP) for analyzing the differences of IOP control, severity of corneal edema, waiting time for laser peripheral iridotomy (LPI), and visual outcome between ACP and Mannitol infusion.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
60

participants targeted

Target at P25-P50 for all trials

Timeline
Completed

Started Jan 2007

Typical duration for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2007

Completed
2.9 years until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2009

Completed
1.1 years until next milestone

First Submitted

Initial submission to the registry

December 22, 2010

Completed
2 days until next milestone

First Posted

Study publicly available on registry

December 24, 2010

Completed
Last Updated

December 24, 2010

Status Verified

December 1, 2010

First QC Date

December 22, 2010

Last Update Submit

December 23, 2010

Conditions

GlaucomaAcute Primary Angle-closure Glaucoma

Keywords

Glaucomaanterior chamber paracentesisconventional Mannitol infusion

Study Arms (2)

Experimental Group

Control Group

Eligibility Criteria

Age20 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Glaucoma patients

You may qualify if:

  • first attack of acute PACG;
  • initial presenting IOP was higher than 45 mmHg;
  • diagnosis confirmed by gonioscopic examination;
  • patients within 48 hours of symptom onset.

You may not qualify if:

  • been incompletely followed up within 2 weeks;
  • been using anti-glaucomatous medication before ACP or Mannitol infusion;
  • previous intraocular surgeries on the same eye;
  • contraindication for Mannitol;
  • history of other vision-threatening ocular diseases.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Taipei Medical University - WanFang Hospital

Taipei, Taiwan

Location

MeSH Terms

Conditions

Glaucoma

Condition Hierarchy (Ancestors)

Ocular HypertensionEye Diseases

Study Officials

  • Hui-Chun Ho

    Taipei Medical University WanFang Hospital

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
CASE CONTROL
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER

Study Record Dates

First Submitted

December 22, 2010

First Posted

December 24, 2010

Study Start

January 1, 2007

Study Completion

December 1, 2009

Last Updated

December 24, 2010

Record last verified: 2010-12

Locations

TW(1)