Differential Diagnosis for the Causes of Subclavian Steal for Patients With Vascular Access in the Forearm

NCT01263301 | Completed Results

• 1 other identifier: 10-06-024-ER
• Study Type: interventional
• Target: 16
• Locations: 1 country
• Sites: 1

Brief Summary

Subclavian steal phenomenon is normally observed in patients with stenosis of subclavian artery proximal to orifice of vertebral artery(V0). However, uremic patients undergoing hemodialysis using vascular access in the arm or forearm may also develop dialysis associated steal syndrome(DASS).For patients with symptomatic subclavian steal phenomenon, the treatment for these two groups is different. The investigators want to see if the investigators can use noninvasive duplex examination instead of invasive conventional angiography to do the differential diagnosis.

Conditions

Subclavian Steal

Keywords

subclavian steal; carotid duplex; subclavian stenosis; hemodialysis with vascular access in the upper limbs; the focus of this study is to see if duplex can be used as an tool to differentiate the different causes of subclavian steal syndromes

Outcome Measures

Primary Outcomes (4)

• Change of Subclavian Flow to Normal Flow Pattern During Cuff Test

  we used carotid duplex duplex to study the change of subclavian arterial flow during cuff test to see if there is any difference between normal participants and patients under hemodialysis. There are two patterns seen. One is that the subclavian arterial flow reversed to normal flow pattern during cuff test. The other is that there is no change of subclavian flow pattern when the flow is stopped in the arm by cuff test.

  two years

• no Change of Subclavian Arterial Flow During Cuff Test

  we used carotid duplex duplex to study the change of subclavian arterial flow during cuff test to see if there is any difference between normal participants and patients under hemodialysis. There are two patterns seen. One is that the subclavian arterial flow reversed to normal flow pattern during cuff test. The other is that there is no change of subclavian flow pattern when the flow is stopped in the arm by cuff test.

  one year

• Change of Vertebral Flow to Normal Flow Pattern During Cuff Test

  we used carotid duplex duplex to study the change of vertebral arterial flow during cuff test to see if there is any difference between normal participants and patients under hemodialysis. There are two patterns seen. One is that the vertebral arterial flow reversed to normal flow pattern during cuff test. The other is that there is no change of vertebral flow pattern when the flow is stopped in the arm by cuff test.

  two year

• no Change of Vertebral Arterial Flow During Cuff Test

  we used carotid duplex duplex to study the change of vertebral arterial flow during cuff test to see if there is any difference between normal participants and patients under hemodialysis. There are two patterns seen. One is that the vertebral arterial flow reversed to normal flow pattern during cuff test. The other is that there is no change of vertebral flow pattern when the flow is stopped in the arm by cuff test.

  2 years

Study Arms (2)

carotid duplex for hemolytic patients wtih SSS

ACTIVE COMPARATOR

assigned intervention:carotid duplex

Device: carotid duplex

carotid duplex for nonhemolytic patients with SSS

ACTIVE COMPARATOR

Device: carotid duplex

Interventions

carotid duplex DEVICE

Carotid duplex in the differential diagnosis of subclavian steal syndrome due to Arteriovenous Hemodialysis access in the Ipsilateral arm

Also known as: steal syndrome

carotid duplex for hemolytic patients wtih SSS; carotid duplex for nonhemolytic patients with SSS

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• patients who revealed subclavian steal in the duplex study

You may not qualify if:

• patients who has vascular access in the arm instead of the forearm

Sponsors & Collaborators

• Mennonite Christian Hospital: lead

Study Sites (1)

Mennonite Christial Hospital

Hualien City, Taiwan, 970, Taiwan

Location

MeSH Terms

Conditions

Subclavian Steal Syndrome

Condition Hierarchy (Ancestors)

Vertebrobasilar Insufficiency; Brain Ischemia; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Limitations and Caveats

the number of the study is small, no standard technique for measurement of blood flow of vascular access

Results Point of Contact

• Title: Ling-Chih Wu MD
• Organization: Mennonite Christian Hospital

lingchihwu@yahoo.com

88638241234

Study Officials

• lingchih wu

  Mennonite Christian Hospital

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: doctor

Study Record Dates

• First Submitted: December 16, 2010
• First Posted: December 20, 2010
• Study Start: August 1, 2010
• Primary Completion: July 1, 2011
• Study Completion: July 1, 2011
• Last Updated: February 12, 2013
• Results First Posted: February 1, 2013

Record last verified: 2013-02

Locations

TW (1)