Trials Sponsors Conditions Drugs Pricing

You may not qualify if:

History of serious adverse reactions or hypersensitivity to any drug; or known allergy to any of the test product(s) or any components in the test product(s) or history of hypersensitivity; or allergic reactions to any of the study preparations as described in the Investigator's Brochure.
Any clinically significant central nervous system (e.g., seizures), cardiac, pulmonary, metabolic, renal, hepatic or gastrointestinal conditions or history of such conditions that, in the opinion of the Investigator may place the subject at an unacceptable risk as a participant in this trial or may interfere with the distribution, metabolism or excretion of drugs.
Abnormal physical findings of clinical significance at the Screening examination or Baseline which would interfere with the objectives of the study.
History of orthostatic hypotension (an increase in HR ≥20 bpm accompanied by a ≥20 mm Hg drop in SBP and/or ≥10 mm Hg drop in DBP) present at Screening.
Clinically significant abnormal laboratory values (as determined by the Investigator) at the Screening evaluation.
Presence or history of allergies requiring acute or chronic treatment (except seasonal allergic rhinitis).
lead ECG obtained at Screening with: PR \>240 msec, QRS \>110 msec and QTc \>450 msec, bradycardia (\<50 bpm) or clinically significant minor ST wave changes on the Screening ECG, or any other changes on the Screening ECG that would interfere with measurement of the QT interval.
Major surgical interventions within 6 months of the study.
Has a positive pre-study Hepatitis B surface antigen; positive Hepatitis C (HCV) antibody or detectable HCV ribonucleic acid (RNA); or positive HIV antibody result.
Use of prescription or non-prescription drugs, including vitamin supplements, herbal and dietary supplements within 7 days or 5 half-lives (whichever is longer) prior to the first dose of study medication, or use of St. John's Wort within 28 days prior to the first dose of study medication. However, the Investigator and study team can review medication use on a case by case basis to determine if its use would compromise subject safety or interfere with study procedures or data interpretation. By exception, the subject may take paracetamol or acetaminophen (≤2 g/day) or ibuprofen (≤1600 mg/day) up to 48 h prior to the first dose of study medication.
Has a history of regular alcohol consumption averaging \>14 drinks/week (1 drink \[100 mL wine or 280 mL standard strength beer or 30 mL of 80 proof distilled spirits\]) within 6 months of the Screening visit.
Loss of 500 mL blood or more during the 3 month period before the study, e.g., blood donor.
People that follow vegetarian or vegan diets.
Symptoms of a significant somatic or mental illness in the four week period preceding drug administration.
History of drug abuse or dependence within 12 months of the study.
+10 more criteria

Safety Study of Ointment for the Treatment of Plaque-type Psoriasis

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

Study Start

Primary Completion

Study Completion

First Submitted

First Posted

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (1)

Study Arms (4)

Cohort 1: AN2728 Ointment

Cohort 1: AN2728 Vehicle

Cohort 3: AN2728 Ointment

Cohort 3: AN2728 Vehicle

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

MeSH Terms

Conditions

Interventions

Condition Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Source record

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

Study Start

Primary Completion

Study Completion

First Submitted

First Posted

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (1)

Study Arms (4)

Cohort 1: AN2728 Ointment

Cohort 1: AN2728 Vehicle

Cohort 3: AN2728 Ointment

Cohort 3: AN2728 Vehicle

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

MeSH Terms

Conditions

Interventions

Condition Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Source record

Locations