NCT01255150|Completed
Frequency of EGFR Mutations in Latinos/Hispanics With Non-Small Cell Lung Cancer
Frequency of Epidermal Growth Factor Receptor Mutations in Latinos/Hispanics With Non-Small Lung Cancer
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Frequency of Epidermal Growth Factor Receptor Mutations in Latinos/Hispanics With Non-Small Lung Cancer
Sponsor study identifier
Secondary identifiers
observational
15
5 countries
12
Study Start
December 1, 2010
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
Not reported
Date not reportedStudy Completion
April 29, 2015
Date type not reportedThis date has not been verified as actual or estimated.
Background: \- Research has shown that the Epidermal Growth Factor Receptor (EGFR) gene is an important target for personalized lung cancer treatment. Individuals who have mutations in the EGFR gene have better responses when treated with certain personalized or targeted therapies compared with conventional chemotherapy. These mutations are more frequent in females with lung cancer who have never smoked, and different ethnic groups have different levels of frequency of the mutations. Researchers are interested in collecting more information on EGFR genetic mutations in Hispanics/Latinos with lung cancer, comparing the frequency of these mutations in males and females and smokers and nonsmokers. This study may lead to better, more personalized care approaches for all individuals with lung cancer. Objectives: \- To study the frequency of Epidermal Growth Factor Receptor mutations in Hispanic/Latino individuals who have been diagnosed with non-small cell lung cancer. Eligibility: \- Hispanic or Latino individuals who have been diagnosed with non-small cell lung cancer and who have lung tissue from a previous biopsy or surgery available for research purposes. Design:
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
April 29, 2015
Date type not reportedThis date has not been verified as actual or estimated.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
December 1, 2010
Date type not reportedThis date has not been verified as actual or estimated.
December 4, 2010
Actual (reported)December 7, 2010
Actual (reported)April 29, 2015
Date type not reportedThis date has not been verified as actual or estimated.
Frequency of EGFR mutations in Hispanic/Latinos with nonsmall cell lung cancer according to gender and smoking status
At tissue and data acquisition upon enrollment
Association between the frequency of EGFR mutations and the percentage of American Indian ancestry, as defined by genetic ancestry analysis, in Hispanic/Latinos with non-small cell lung cancer
At tissue and data acquisition upon enrollment
Denver Health Medical Center
Denver, Colorado, 80204, United States
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, 20892, United States
Kettering Health Network
Kettering, Ohio, 45429, United States
Oregon Health and Sciences Universtiy Cancer Center
Portland, Oregon, 97239, United States
University of Texas Southwestern Medical Center
Dallas, Texas, 75390, United States
Universidad Mayor de San Simon
Cochabamba, Bolivia
Universidad de Colima
Farjah F, Wood DE, Yanez ND 3rd, Vaughan TL, Symons RG, Krishnadasan B, Flum DR. Racial disparities among patients with lung cancer who were recommended operative therapy. Arch Surg. 2009 Jan;144(1):14-8. doi: 10.1001/archsurg.2008.519.
Wisnivesky JP, McGinn T, Henschke C, Hebert P, Iannuzzi MC, Halm EA. Ethnic disparities in the treatment of stage I non-small cell lung cancer. Am J Respir Crit Care Med. 2005 May 15;171(10):1158-63. doi: 10.1164/rccm.200411-1475OC. Epub 2005 Feb 25.
Arun Rajan, M.D.
National Cancer Institute (NCI)
15 participants (actual enrollment reported by the registry).
First Submitted
December 4, 2010
First Posted
December 7, 2010
Study Start
December 1, 2010
Date type not reportedThis date has not been verified as actual or estimated.
Contact the study team to confirm eligibility.
Colima, 28040, Mexico
Instituto Nacional de Cancerologia
Mexico City, 14080, Mexico
Center for Research & Development in Health Sciences
Monterrey, 64460, Mexico
Universidad Autonoma de Queretaro
Querétaro, Mexico
Instituto Nacional de Enfermedades Neoplasicas (INEN)
Lima, Peru
Instituto de Oncologia Luis Razetti
Caracas, Venezuela
Clegg LX, Li FP, Hankey BF, Chu K, Edwards BK. Cancer survival among US whites and minorities: a SEER (Surveillance, Epidemiology, and End Results) Program population-based study. Arch Intern Med. 2002 Sep 23;162(17):1985-93. doi: 10.1001/archinte.162.17.1985.
Study Completion
April 29, 2015
Date type not reportedThis date has not been verified as actual or estimated.
Last Updated
November 21, 2019
Record last verified: 2015-04-29
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Source: ClinicalTrials.gov.
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