NCT01251718

Brief Summary

To investigate the clinical safety and effectiveness of donepezil hydrochloride administration in patients with mild or moderate Alzheimer's Disease

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
894

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Dec 2010

Longer than P75 for all trials

Geographic Reach
1 country

106 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

December 1, 2010

Completed
Same day until next milestone

Study Start

First participant enrolled

December 1, 2010

Completed
1 day until next milestone

First Posted

Study publicly available on registry

December 2, 2010

Completed
4.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 14, 2015

Completed
4 months until next milestone

Study Completion

Last participant's last visit for all outcomes

February 18, 2016

Completed
Last Updated

July 24, 2023

Status Verified

January 1, 2017

Enrollment Period

4.9 years

First QC Date

December 1, 2010

Last Update Submit

July 21, 2023

Conditions

Keywords

Donepezil hydrochlorideAlzheimer's Disease

Outcome Measures

Primary Outcomes (1)

  • ADAS-Jcog (test of cognitive function)

    36 month (12 weeks and every 6 months)

Secondary Outcomes (1)

  • Adverse events/adverse drug reactions

    36 months

Study Arms (1)

Donepezil Hydrochloride

Drug: donepezil hydrochloride

Interventions

Initial dose of 3 mg orally once daily. After 1-2 weeks, dosage increased to 5 mg orally once daily. After 4 or more weeks, dosage increased to 10 mg orally once daily for patients with severe dementia of Alzheimer's type. Dose reduced appropriately according to patient's symptoms.

Donepezil Hydrochloride

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patients with Alzheimer's Disease

You may qualify if:

  • Patients diagnosed as Alzheimer's Disease by Diagnostic and Statistical Manual of Mental Disorders (DSM-IV).
  • Patients diagnosed as mild or moderate Alzheimer's Disease, applicable to Functional Assessment Staging (FAST) score 4 or 5.

You may not qualify if:

  • Patients who used Aricept within 3 months prior to dosing.
  • Patients registered this survey before.
  • Patients with a history of hypersensitivity to any ingredients of Aricept or piperidine derivatives.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (106)

Unknown Facility

Anjo, Aichi-ken, Japan

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Nagoya, Aichi-ken, Japan

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Daisen, Akita, Japan

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Hirosaki, Aomori, Japan

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Towada, Aomori, Japan

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Ichihara, Chiba, Japan

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Kashiwa, Chiba, Japan

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Sakura, Chiba, Japan

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Iyo, Ehime, Japan

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Matsuyama, Ehime, Japan

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Niihama, Ehime, Japan

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Tōon, Ehime, Japan

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Kitakyushu, Fukuoka, Japan

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Omuta, Fukuoka, Japan

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Ukiha, Fukuoka, Japan

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Iwaki, Fukushima, Japan

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Mizunami, Gifu, Japan

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Fujioka, Gunma, Japan

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Fukuyama, Hiroshima, Japan

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Kure, Hiroshima, Japan

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Miyoshi, Hiroshima, Japan

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Ōtake, Hiroshima, Japan

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Hakodate, Hokkaido, Japan

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Nayoro, Hokkaido, Japan

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Obihiro, Hokkaido, Japan

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Otaru, Hokkaido, Japan

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Sapporo, Hokkaido, Japan

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Sunagawa, Hokkaido, Japan

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Aioi, Hyōgo, Japan

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Akashi, Hyōgo, Japan

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Amagasaki, Hyōgo, Japan

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Himeji, Hyōgo, Japan

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Kobe, Hyōgo, Japan

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Moriya, Ibaraki, Japan

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Kanazawa, Ishikawa-ken, Japan

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Kita, Kagawa-ken, Japan

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Mitoyo, Kagawa-ken, Japan

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Ebina, Kanagawa, Japan

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Kawasaki, Kanagawa, Japan

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Yokohama, Kanagawa, Japan

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Yokosuka, Kanagawa, Japan

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Nankoku, Kochi, Japan

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Uji, Kyoto, Japan

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Suzuka, Mie-ken, Japan

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Tsu, Mie-ken, Japan

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Yokkaichi, Mie-ken, Japan

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Sendai, Miyagi, Japan

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Kitamorokata, Miyazaki, Japan

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Iida, Nagano, Japan

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Matsumoto, Nagano, Japan

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Okaya, Nagano, Japan

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Sasebo, Nagasaki, Japan

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Ikoma, Nara, Japan

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Kashihara, Nara, Japan

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Saiki, Oita Prefecture, Japan

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Yufu, Oita Prefecture, Japan

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Kurashiki, Okayama-ken, Japan

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Izumisano, Osaka, Japan

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Kaizuka, Osaka, Japan

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Matsubara, Osaka, Japan

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Sakai, Osaka, Japan

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Sayama, Osaka, Japan

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Suita, Osaka, Japan

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Fukaya, Saitama, Japan

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Hannō, Saitama, Japan

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Iruma, Saitama, Japan

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Koshigaya, Saitama, Japan

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Sayama, Saitama, Japan

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Masuda, Shimane, Japan

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Hamamatsu, Shizuoka, Japan

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Adachi City, Tokyo, Japan

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Bunkyo, Tokyo, Japan

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Hachiōji, Tokyo, Japan

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Katsushika-ku, Tokyo, Japan

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Machida, Tokyo, Japan

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Meguro City, Tokyo, Japan

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Minato, Tokyo, Japan

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Nakano City, Tokyo, Japan

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Setagaya City, Tokyo, Japan

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Shinjuku, Tokyo, Japan

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tabashi City, Tokyo, Japan

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Taitō City, Tokyo, Japan

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Toshima City, Tokyo, Japan

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Kurayoshi, Tottori, Japan

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Nanto, Toyama, Japan

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Kinokawa, Wakayama, Japan

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Tendō, Yamagata, Japan

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Hagi, Yamaguchi, Japan

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Shūnan, Yamaguchi, Japan

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Ube, Yamaguchi, Japan

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Akita, Japan

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Chiba, Japan

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Fukuoka, Japan

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Fukushima, Japan

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Gifu, Japan

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Hiroshima, Japan

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Kagoshima, Japan

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Kochi, Japan

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Kyoto, Japan

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Nara, Japan

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Niigata, Japan

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Okayama, Japan

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Osaka, Japan

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Ōita, Japan

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Shizuoka, Japan

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Yamanashi, Japan

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MeSH Terms

Conditions

Alzheimer Disease

Interventions

Donepezil

Condition Hierarchy (Ancestors)

DementiaBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesTauopathiesNeurodegenerative DiseasesNeurocognitive DisordersMental Disorders

Intervention Hierarchy (Ancestors)

IndansIndenesPolycyclic Aromatic HydrocarbonsHydrocarbons, AromaticHydrocarbons, CyclicHydrocarbonsOrganic ChemicalsPiperidinesHeterocyclic Compounds, 1-RingHeterocyclic CompoundsPolycyclic Compounds

Study Officials

  • Shoya Yamakawa

    Drug Fostering and Evolution Coordination Department, Eisai Co., Ltd.

    STUDY DIRECTOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

December 1, 2010

First Posted

December 2, 2010

Study Start

December 1, 2010

Primary Completion

October 14, 2015

Study Completion

February 18, 2016

Last Updated

July 24, 2023

Record last verified: 2017-01

Locations