Sensory Attention Focused Exercise in Parkinson's Disease

NCT01246700 | Unknown

• 1 other identifier: 225510
• Study Type: interventional
• Target: 76
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is 1.) to determine if sensory attention focused exercise is an effective management strategy for Parkinson's disease, and 2.) to identify if the benefits are a result of strength gains.

Conditions

Parkinson's Disease

Keywords

Parkinson's disease; Randomized single-blind crossover trial; Sensory Attention Focused Exercise

Outcome Measures

Primary Outcomes (1)

• Unified Parkinson's Disease Rating Scale (UPDRS) III (motor score)

  Assessment of patient's disease severity, completed by a blinded certified clinician.

  Baseline, 12 weeks and 24 weeks

Secondary Outcomes (7)

• Timed up and go

  Baseline, 12 weeks and 24 weeks

• 30 second chair stand

  Baseline, 12 weeks and 24 weeks

• Unified Parkinson's Disease Rating Scale (UPDRS) - I and II (self report of mentation, depression, and activities of daily living).

  Baseline, 12 weeks and 24 weeks

• Grooved Pegboard

  Baseline, 12 weeks and 24 weeks

• Step Length

  Baseline, 12 weeks and 24 weeks

Study Arms (2)

Group A

EXPERIMENTAL

Participants received 12 weeks of Sensory Attention Focused Exercise, then received 12 weeks of no exercise.

Other: Sensory Attention Focused Exercise (SAFEx)

Group B

EXPERIMENTAL

Participants received no treatment for 12 weeks, then received Sensory Attention Focused Exercise for 12 weeks.

Other: Sensory Attention Focused Exercise (SAFEx)

Interventions

Sensory Attention Focused Exercise (SAFEx) OTHER

Consisted of 12 weeks for SAFEx intervention, 3 times a week for an hour each session. Participants complete dynamic balance activities and a variety of seated stretches and range of motion activities. Participants are cued to focus on sensation and proprioception of limbs. Group A received SAFEx for 12 weeks then received no treatment for 12 weeks.

Group A

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• diagnosis of PD by a clinician/neurologist
• absence of mentation
• established medication schedule and dosage

You may not qualify if:

• mentation
• change in medication during period of study
• change in exercise level during period of study
• inability to complete the exercise program
• absence of 5 or more classes, or absence of 3 or more classes in sequence

Sponsors & Collaborators

• Sun Life Financial Movement Disorders Research and Rehabilitation Centre: lead
• Canada, Young Men's Christian Association (YMCA): collaborator
• Parkinson Society Canada: collaborator
• Canada, Sun Life Financial: collaborator
• Canadian Institutes of Health Research (CIHR): collaborator

Study Sites (1)

Sun Life Financial Movement Disorders Research and Rehabilitation Centre

Waterloo, Ontario, N2L 3J4, Canada

Location

Related Publications (6)

• Sage MD, Almeida QJ. Symptom and gait changes after sensory attention focused exercise vs aerobic training in Parkinson's disease. Mov Disord. 2009 Jun 15;24(8):1132-8. doi: 10.1002/mds.22469.

  PMID: 19373930 BACKGROUND

• Sage MD, Almeida QJ. A positive influence of vision on motor symptoms during sensory attention focused exercise for Parkinson's disease. Mov Disord. 2010 Jan 15;25(1):64-9. doi: 10.1002/mds.22886.

  PMID: 19938164 BACKGROUND

• Nieuwboer A, Kwakkel G, Rochester L, Jones D, van Wegen E, Willems AM, Chavret F, Hetherington V, Baker K, Lim I. Cueing training in the home improves gait-related mobility in Parkinson's disease: the RESCUE trial. J Neurol Neurosurg Psychiatry. 2007 Feb;78(2):134-40. doi: 10.1136/jnnp.200X.097923.

  PMID: 17229744 BACKGROUND

• Comella CL, Stebbins GT, Brown-Toms N, Goetz CG. Physical therapy and Parkinson's disease: a controlled clinical trial. Neurology. 1994 Mar;44(3 Pt 1):376-8. doi: 10.1212/wnl.44.3_part_1.376.

  PMID: 8145901 BACKGROUND

• Ernst M, Folkerts AK, Gollan R, Lieker E, Caro-Valenzuela J, Adams A, Cryns N, Monsef I, Dresen A, Roheger M, Eggers C, Skoetz N, Kalbe E. Physical exercise for people with Parkinson's disease: a systematic review and network meta-analysis. Cochrane Database Syst Rev. 2024 Apr 8;4(4):CD013856. doi: 10.1002/14651858.CD013856.pub3.

  PMID: 38588457 DERIVED

• Ernst M, Folkerts AK, Gollan R, Lieker E, Caro-Valenzuela J, Adams A, Cryns N, Monsef I, Dresen A, Roheger M, Eggers C, Skoetz N, Kalbe E. Physical exercise for people with Parkinson's disease: a systematic review and network meta-analysis. Cochrane Database Syst Rev. 2023 Jan 5;1(1):CD013856. doi: 10.1002/14651858.CD013856.pub2.

  PMID: 36602886 DERIVED

Related Links

• The Sun Life Movement Disorders Research and Rehabilitation Centre, based out of Wilfrid Laurier University, facilitates relevant research on Parkinson's disease.

MeSH Terms

Conditions

Parkinson Disease

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases

Study Officials

• Quincy J Almeida, Ph.D

  Sun Life Financial Movement Disorders Research and Rehabilitation Centre

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: November 22, 2010
• First Posted: November 23, 2010
• Study Start: June 1, 2008
• Primary Completion: December 1, 2009
• Study Completion: December 1, 2010
• Last Updated: November 23, 2010

Record last verified: 2010-09

Locations

CA (1)