NCT01246414

Brief Summary

This study aims to compare the inflammatory mediators in exhaled breathe condensates from allergic and non-allergic asthmatic patients.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
38

participants targeted

Target at P25-P50 for all trials

Timeline
Completed

Started Jan 2010

Shorter than P25 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2010

Completed
3 days until next milestone

First Submitted

Initial submission to the registry

January 4, 2010

Completed
3 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 1, 2010

Completed
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

May 1, 2010

Completed
7 months until next milestone

First Posted

Study publicly available on registry

November 23, 2010

Completed
Last Updated

November 23, 2010

Status Verified

November 1, 2010

Enrollment Period

3 months

First QC Date

January 4, 2010

Last Update Submit

November 22, 2010

Conditions

Asthma

Keywords

AsthmaExhaled breath condensatesCytokines

Outcome Measures

Primary Outcomes (1)

  • Levels of inflammatory cytokines in exhaled breathe condensates

    4 months

Study Arms (3)

Allergic asthma

Patients with allergic asthma

Non-allergic asthma

Patients with non-allergic asthma

Non-asthmatic controls

Non-asthmatic controls

Eligibility Criteria

Age15 Years - 65 Years
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Asthmatic patients in Allergy clinic, King Chulalongkorn Memorial Hospital (10 allergic and 10 non-allergic) and 10 non-asthmatic controls will be enrolled to this study to collect exhaled breathe condensates (EBC) and measure levels of inflammatory cytokines in EBC

You may qualify if:

  • Have been diagnosed as asthma at least 6 months before enrolled to the study
  • Known skin prick test results to aeroallergens ; either positive or negative
  • years of age

You may not qualify if:

  • On oral or inhaled corticosteroids within 1 month before the study
  • Having asthma exacerbation
  • Being pregnant
  • Suffering from severe systemic disease/ in bad health

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Chulalongkorn University

Bangkok, 10330, Thailand

Location

Related Publications (1)

  • Boonpiyathad S, Pornsuriyasak P, Buranapraditkun S, Klaewsongkram J. Interleukin-2 levels in exhaled breath condensates, asthma severity, and asthma control in nonallergic asthma. Allergy Asthma Proc. 2013 Sep-Oct;34(5):e35-41. doi: 10.2500/aap.2013.34.3680.

    PMID: 23998235DERIVED

Biospecimen

Retention: SAMPLES WITHOUT DNA

Exhaled breathe condensates

MeSH Terms

Conditions

Asthma

Condition Hierarchy (Ancestors)

Bronchial DiseasesRespiratory Tract DiseasesLung Diseases, ObstructiveLung DiseasesRespiratory HypersensitivityHypersensitivity, ImmediateHypersensitivityImmune System Diseases

Study Officials

  • Jettanong Klaewsongkram, MD

    Chulalongkorn University

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
CROSS SECTIONAL
Sponsor Type
OTHER

Study Record Dates

First Submitted

January 4, 2010

First Posted

November 23, 2010

Study Start

January 1, 2010

Primary Completion

April 1, 2010

Study Completion

May 1, 2010

Last Updated

November 23, 2010

Record last verified: 2010-11

Locations

TH(1)