Effect of Remifentanil on Cough During Emergence From General Anesthesia : Trial to Compare Between Sevoflurane Anesthesia and Propofol Anesthesia
1 other identifier
interventional
70
1 country
1
Brief Summary
The objective of this study was to compare the effect of remifentanil on suppression cough reflex during emergence in patient anesthetized using either propofol or sevoflurane additionally under infusion of the identical concentration of remifentanil.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for phase_4
Started Sep 2010
Shorter than P25 for phase_4
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 1, 2010
CompletedFirst Submitted
Initial submission to the registry
November 10, 2010
CompletedFirst Posted
Study publicly available on registry
November 15, 2010
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 1, 2011
CompletedStudy Completion
Last participant's last visit for all outcomes
February 1, 2011
CompletedMay 13, 2011
May 1, 2011
4 months
November 10, 2010
May 12, 2011
Conditions
Study Arms (2)
propofol
ACTIVE COMPARATORsevoflurane
ACTIVE COMPARATORInterventions
* propofol group : propofol effect site-TCI 2-4mcg/ml + remifentanil effect site-TCI 2-4ng/ml * sevoflurane group: sevoflurane end-tidal concentration 0.5-1.0 MAC + remifentanil effect site-TCI 2-4ng/ml
Eligibility Criteria
You may qualify if:
- females
- ASA I-II
- aged between 20 and 70 year
- general anesthesia for elective thyroidectomy
You may not qualify if:
- signs of an anatomical or functional abnormality in upper airway
- risk factors for perioperative aspiration
- smoking for recent 8 weeks
- URI or sore throat for recent 2 weeks
- potential of pregnancy
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Severance Hospital
Seoul, 120-752, South Korea
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Jeong-Rim Lee, MD, Ph.D
Severance Hospital, Department of Anesthesiology and Pain Medicine
Study Design
- Study Type
- interventional
- Phase
- phase 4
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, INVESTIGATOR
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
November 10, 2010
First Posted
November 15, 2010
Study Start
September 1, 2010
Primary Completion
January 1, 2011
Study Completion
February 1, 2011
Last Updated
May 13, 2011
Record last verified: 2011-05