NCT01237145|Completed
Bronchoalveolar Immune Response Determination
BIRD
Study to Determine the Immune Response From Broncho-alveolar Cells Against Pigeon Specific Antigens
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BIRD
Study to Determine the Immune Response From Broncho-alveolar Cells Against Pigeon Specific Antigens
Sponsor study identifier
observational
10
1 country
1
Study Start
September 2011
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
September 2012
Actual (reported)Study Completion
December 2012
Actual (reported)The purpose of this study is to establish if cells present in lung tissue during extrinsic allergic alveolitis (EAA) are able to elicit an immune response against specific antigens. The hypothesis is: cells in BAL lavage fluid from patients with EAA will be responsive to specific antigens and this response can be measured using ELISPOT.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 2012
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
November 7, 2010
Actual (reported)November 9, 2010
Actual (reported)September 2011
Date type not reportedThis date has not been verified as actual or estimated.
September 2012
Actual (reported)December 2012
Actual (reported)ELISPOT response in cells obtained from broncho-alveolar lavage
All elispots will be performed the same day, the end point will be available the next day
2 days
Elispot response in cells from blood
2 days
subject with BAL because of diseases not suspected to be EAA
Bird fanciers with a typical clinical presentation suspected for pigeon induced EAA
Patients suspected to have pigeon induced extrinsic allergic alveolitis will be recruited by advertisment in bird fanciers journals. Controls will be patients at the department of pulmonology and tuberculosis needing examination for other reasons
Diakonessenhuis Utrecht
Utrecht, 3582 KE, Netherlands
Jafari C, Thijsen S, Sotgiu G, Goletti D, Dominguez Benitez JA, Losi M, Eberhardt R, Kirsten D, Kalsdorf B, Bossink A, Latorre I, Migliori GB, Strassburg A, Winteroll S, Greinert U, Richeldi L, Ernst M, Lange C; Tuberculosis Network European Trialsgroup. Bronchoalveolar lavage enzyme-linked immunospot for a rapid diagnosis of tuberculosis: a Tuberculosis Network European Trialsgroup study. Am J Respir Crit Care Med. 2009 Oct 1;180(7):666-73. doi: 10.1164/rccm.200904-0557OC. Epub 2009 Jul 9.
Losi M, Bossink A, Codecasa L, Jafari C, Ernst M, Thijsen S, Cirillo D, Ferrarese M, Greinert U, Fabbri LM, Richeldi L, Lange C; European Tuberculosis Network TBNET. Use of a T-cell interferon-gamma release assay for the diagnosis of tuberculous pleurisy. Eur Respir J. 2007 Dec;30(6):1173-9. doi: 10.1183/09031936.00067307. Epub 2007 Aug 22.
Cells obtained from Broncho alveolar lavage and blood collection
Aik Bossink, MD PhD
Diakonessenhuis, Utrecht
10 participants (actual enrollment reported by the registry).
First Submitted
November 7, 2010
First Posted
November 9, 2010
Study Start
September 2011
Date type not reportedThis date has not been verified as actual or estimated.
This Study Aim is to Compare the Effect of Oral Methyl Prednisolone on Different Radiological Patterns of Hypersensitivity Pneumonitis as it Was Found That Not All Patients Get Satisfying Therapeutic Effect After Taking Corticosteroids.
Contact the study team to confirm eligibility.
Kosters K, Nau R, Bossink A, Greiffendorf I, Jentsch M, Ernst M, Thijsen S, Hinks T, Lalvani A, Lange C. Rapid diagnosis of CNS tuberculosis by a T-cell interferon-gamma release assay on cerebrospinal fluid mononuclear cells. Infection. 2008 Dec;36(6):597-600. doi: 10.1007/s15010-007-7316-0. Epub 2008 Jan 12.
Primary Completion
September 2012
Actual (reported)Study Completion
December 2012
Actual (reported)Last Updated
January 19, 2018
Record last verified: 2018-01
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