Differential Diagnosis of STA-PSV in Thyrotoxicosis

NCT01227499 | Completed DMC

• 1 other identifier: huashan001
• Study Type: observational
• Target: 169
• Locations: 1 country
• Sites: 1

Brief Summary

Aim: Graves's disease and thyroiditis can both characterized with thyrotoxicosis, but their clinical outcome and therapy is quiet different. Measurement of iodine uptake is the gold standard to differential diagnosis the thyroiditis or Graves's disease. But the iodine uptake is limited for its availability in china and easily influenced by medicine or food contained iodine.The blood pattern of thyroid CFDS is useful for differentiate the cause of thyrotoxicosis.Most previous studies using the descriptive pattern of thyroid CFDS is easily varied by operator subjective judgement. This study is focus on the role of peak systolic velocity of thyroid superior artery in differential diagnosis of thyrotoxicosis. Methods: Patients with thyrotoxicosis symptoms without recent medicine history were enrolled in two clinical center. Its thyroid function, iodine uptake , CFDS of thyroid and peak systolic velocity of thyroid superior artery is detected. Thyrotoxicosis is defined as TSH level below the low value of normal range. Graves disease is defined as the typical symptoms of graves disease such as graves ophthalmopathy or increased iodine uptake. Thyroiditis is defined as lack of typical symptoms of graves disease or decreased iodine uptake.We use receiver operator curve(ROC) to evaluate its diagnosis value

Conditions

Thyrotoxicosis; Peak Systolic Velocity of Superior Thyroid Artery; Thyroiditis; Graves Disease

Outcome Measures

Primary Outcomes (2)

• mean STA-PSV

  the mean STA-PSV

  2014-04-07

• uptake of iodine

  December 1, 2013

Secondary Outcomes (1)

• PSV

  December 1, 2013

Other Outcomes (1)

• thyroid funciton

  December 1, 2013

Eligibility Criteria

• Age: 15 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

primary care clinic

You may qualify if:

• newly diagnosed without taking any antithyroid drug or beta receptor blocker with TSH level below the lower limits of reference range
• is willing to be enrolled

You may not qualify if:

• unwilling
• taking antithyroid drug or beta receptor blocker
• taking foods or medicine rich in iodine in 8 weeks
• women with pregnant or lactation

Sponsors & Collaborators

• xiaolong zhao: lead
• Zhongda Hospital: collaborator
• Fudan University: collaborator

Study Sites (1)

Xiaolong Zhao

Shanghai, Shanghai Municipality, 200040, China

Location

Related Publications (1)

• Zhao X, Chen L, Li L, Wang Y, Wang Y, Zhou L, Zeng F, Li Y, Hu R, Liu H. Peak systolic velocity of superior thyroid artery for the differential diagnosis of thyrotoxicosis. PLoS One. 2012;7(11):e50051. doi: 10.1371/journal.pone.0050051. Epub 2012 Nov 16.

  PMID: 23166817 RESULT

MeSH Terms

Conditions

Thyrotoxicosis; Thyroiditis; Graves Disease

Condition Hierarchy (Ancestors)

Hyperthyroidism; Thyroid Diseases; Endocrine System Diseases; Exophthalmos; Orbital Diseases; Eye Diseases; Goiter; Autoimmune Diseases; Immune System Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: endocrinology department

Study Record Dates

• First Submitted: October 22, 2010
• First Posted: October 25, 2010
• Study Start: June 1, 2010
• Primary Completion: November 1, 2011
• Study Completion: November 1, 2011
• Last Updated: May 5, 2014

Record last verified: 2014-05

Locations

CN (1)