Decision-making and Emotion Recognition in Essential Tremor

NCT01223144 | Completed

• 1 other identifier: CHUBX 2010/10
• Study Type: interventional
• Target: 39
• Locations: 1 country
• Sites: 1

Brief Summary

The present study aims at investigating cognitive functions requiring orbitofrontal control, namely decision-making and facial emotion recognition. The investigators hypothesize that decision-making and facial emotion recognition are impaired in patients with essential tremor (ET) due to frontal lobe dysfunction which may have consequences in daily social life.

Conditions

Essential Tremor

Keywords

Cognition; orbitofrontal cortex; Iowa Gambling Task; facial emotion recognition

Outcome Measures

Primary Outcomes (1)

• Comparison of the performance in the Iowa Gambling Task and the Ekman facial recognition test

  Comparison of the performance in the Iowa Gambling Task and the Ekman facial recognition test between patients and age- and sex-matched controls. * Iowa Gambling Task: mean number of cards chosen from decks with low (A+B) and high gain (C+D). * Ekman facial recognition test: mean number of faces correctly recognized (60 images with 6 different expressions: happiness, sadness, fear, surprise, disgust and anger).

  1 day (duration of study)

Secondary Outcomes (3)

• Risk anticipation as assessed by the number of advantageous minus disadvantageous choices in the Iowa Gambling Task.

  1 day (duration of study)

• Assessment of the relation between the primary outcome measures and age, sex, disease duration, as well as tremor severity.

  1 day (duration of study)

• Assessment of the relation between the primary outcome measures and executive function and depression.

  1 day (duration of study)

Study Arms (2)

Patients with essential tremor

EXPERIMENTAL

Patients with essential tremor

Behavioral: Iowa Gambling Task and Ekman facial recognition test

age- and sex-matched control subjects

ACTIVE COMPARATOR

age- and sex-matched control subjects

Behavioral: Iowa Gambling Task and Ekman facial recognition test

Interventions

Iowa Gambling Task and Ekman facial recognition test BEHAVIORAL

Iowa Gambling Task: mean number of cards chosen from decks with low (A+B) and high gain (C+D). Ekman facial recognition test: mean number of faces correctly recognized (60 images with 6 different expressions: happiness, sadness, fear, surprise, disgust and anger).

Patients with essential tremor; age- and sex-matched control subjects

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patient:
• Age over 18 years
• Patient diagnosed as having essential tremor
• Written informed consent
• Patient covered by the French health insurance system
• Control:
• Age over 18 years
• No diagnosis of essential tremor
• Written informed consent
• Subject covered by the French health insurance system

You may not qualify if:

• Patient:
• Dementia (MMSE\<24) or other known illness which could impact motor and cognitive performances
• Patient unable to give written informed consent
• Control:

Sponsors & Collaborators

• University Hospital, Bordeaux: lead

Study Sites (1)

CHU de Bordeaux, Hôpital du Haut-Lévêque

Pessac, 33604, France

Location

MeSH Terms

Conditions

Essential Tremor

Condition Hierarchy (Ancestors)

Movement Disorders; Central Nervous System Diseases; Nervous System Diseases

Study Officials

• Wassilios Meissner, MD, PhD

  University Hospital Bordeaux, France

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 15, 2010
• First Posted: October 18, 2010
• Study Start: September 1, 2010
• Primary Completion: December 1, 2011
• Study Completion: December 1, 2011
• Last Updated: June 8, 2012

Record last verified: 2012-06

Locations

FR (1)