Exercise as a Strategy to Treat Cognitive Dysfunction in Persons With Multiple Sclerosis
CogEx
1 other identifier
interventional
35
1 country
2
Brief Summary
Many persons with Multiple Sclerosis ( MS) have problems with memory and thinking.Exercise has been shown to improve memory and thinking in persons with diseases such as Alzheimer's. This study will investigate whether a program of aerobic exercise can improve memory and thinking in persons with MS
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for phase_1 multiple-sclerosis
Started Jul 2010
Typical duration for phase_1 multiple-sclerosis
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
July 1, 2010
CompletedFirst Submitted
Initial submission to the registry
October 8, 2010
CompletedFirst Posted
Study publicly available on registry
October 13, 2010
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 1, 2014
CompletedStudy Completion
Last participant's last visit for all outcomes
August 1, 2014
CompletedDecember 9, 2014
December 1, 2014
4.1 years
October 8, 2010
December 5, 2014
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Paced Auditory Serial Addition Test (PASAT)
test of attention and information processing
36 weeks
Secondary Outcomes (3)
Symbol Digit Modalities Test (SDMT)
36 weeks
VO2 max
36 weeks
Long latency cognitive event related potentials ( LLCERP)
36 weeks
Study Arms (2)
aerobic exercise
EXPERIMENTALSubjects will train on a recumbent cross trainer 20-30 minutes/session for three times/week for six months under supervision of a fitness specialist
stretching
ACTIVE COMPARATORSubjects will particiate in supervised stretching at same frauency, duration and intensity of aerobic exericse arm
Interventions
subjects will particiopate in supervised stretching as described in arm description.
Eligibility Criteria
You may qualify if:
- Clinical Diagnosis of MS Complaints of cognitive problems Able to ride a recumbent cross trainer
You may not qualify if:
- Cardiopulmonary or structural disease that would limit ability to participate in exercise training On treatment with chemotherapy or natalizumab Screening score of \>50 on PASAT
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (2)
UCalifornia at Los Angeles
Los Angeles, California, 90095, United States
CAl State University at Northridge
Northridge, California, 91330, United States
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Barbara Giesser, MD
University of California, Los Angeles
Study Design
- Study Type
- interventional
- Phase
- phase 1
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Clincial Profesor of Neurology
Study Record Dates
First Submitted
October 8, 2010
First Posted
October 13, 2010
Study Start
July 1, 2010
Primary Completion
August 1, 2014
Study Completion
August 1, 2014
Last Updated
December 9, 2014
Record last verified: 2014-12