Study Stopped
terminated
Methylprednisolone Pulse Macrolide Therapy for Refractory Mycoplasma Pneumoniae Pneumonia in Children
MPP
A Prospective, Open-label Trial of Methylprednisolone Pulse Macrolide Therapy for Refractory Mycoplasma Pneumoniae Pneumonia in Children
1 other identifier
interventional
47
0 countries
N/A
Brief Summary
The purpose of this study is planned to investigate whether small doses of methylprednisolone pulse macrolide therapy can relieve symptoms,chest X-rays faster than macrolide alone therapy for refractory mycoplasma pneumoniae pneumonia(MPP) .
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started May 2007
Typical duration for not_applicable
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 1, 2007
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 1, 2010
CompletedStudy Completion
Last participant's last visit for all outcomes
May 1, 2010
CompletedFirst Submitted
Initial submission to the registry
October 6, 2010
CompletedFirst Posted
Study publicly available on registry
October 8, 2010
CompletedOctober 8, 2010
May 1, 2007
3 years
October 6, 2010
October 7, 2010
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
efficacy of methylprednisolone pulse macrolide therapy for children with refractory MPP.
compare the temperature , infiltration absorption,atelectasis resolution, pleural effusion disappearance,serum levels of ferritin and LDH between methylprednisolone pulse macrolide therapy group and macrolide therapy group .
3-year
Secondary Outcomes (1)
safety of methylprednisolone pulse macrolide therapy for children with refractory MPP.
3-year
Study Arms (2)
methylprednisolone
NO INTERVENTIONmethylprednisolone pulse azithromycin
azithromycin
NO INTERVENTIONazithromycin
Interventions
treatment patients were iv methylprednisolone pulse azithromycin for 5 days.
control patients were iv azithromycin for 5 days.
Eligibility Criteria
You may qualify if:
- mycoplasma pneumoniae pneumonia
- prolonged fever and deterioration of radiological findings despite macrolides treatment for 7 days or more.
You may not qualify if:
- chronic cardiac and pulmonary disease
- immunodeficiency
- requiring mechanical ventilation
- with other pathogens detected during pneumonia.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Related Links
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
zhengxiu luo, doctor
Chongqing Medical University
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NON RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
October 6, 2010
First Posted
October 8, 2010
Study Start
May 1, 2007
Primary Completion
May 1, 2010
Study Completion
May 1, 2010
Last Updated
October 8, 2010
Record last verified: 2007-05