NCT01214070

Brief Summary

The objective of this study is to test functional vision outcome measures that reflect the loss in everyday life tasks that require vision and that are sensitive to changes after a course of vision rehabilitation in Veterans/participants with TBI.

Trial Health

57
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
110

participants targeted

Target at P50-P75 for phase_4

Timeline
Completed

Started Jun 2012

Geographic Reach
1 country

1 active site

Status
terminated

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

September 14, 2010

Completed
20 days until next milestone

First Posted

Study publicly available on registry

October 4, 2010

Completed
1.7 years until next milestone

Study Start

First participant enrolled

June 1, 2012

Completed
1.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 21, 2013

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

November 21, 2013

Completed
Last Updated

June 16, 2017

Status Verified

June 1, 2017

Enrollment Period

1.5 years

First QC Date

September 14, 2010

Last Update Submit

June 14, 2017

Conditions

Keywords

Visual PerceptionVision, OcularNeuronal Plasticity

Outcome Measures

Primary Outcomes (1)

  • Dynamic Visual Field

    Baseline

Secondary Outcomes (8)

  • Dynamic Visual Field

    After First Therapy / Before Second Therapy (Average time is 4.5 months)

  • Dynamic Visual Field

    After Second Therapy (Average Time is 9 months)

  • Reading Rate and Accuracy

    Baseline

  • Reading Rate

    After First Therapy / Before Second Therapy (average time is 4.5 months)

  • Reading Rate and Accuracy

    After Second Therapy (average time is 9 months)

  • +3 more secondary outcomes

Study Arms (7)

Arm 1

ACTIVE COMPARATOR

Group 1 - Combination Treatment

Other: Vision Restoration TherapyBehavioral: NVT Eye Scanning Therapy

Arm 2

ACTIVE COMPARATOR

Group 2 - Combination Treatment

Behavioral: Eccentric Viewing Training

Arm 3

ACTIVE COMPARATOR

Group 3 - Combination Treatment

Other: Vision Restoration TherapyBehavioral: NVT Eye Scanning Therapy

Arm 4

ACTIVE COMPARATOR

Group 4 - Combination Treatment

Behavioral: Eccentric Viewing Training

Arm 5

ACTIVE COMPARATOR

Group 5 - Monotherapy Treatment

Other: Vision Restoration TherapyBehavioral: Sham

Arm 6

ACTIVE COMPARATOR

Group 6 - Monotherapy Treatment

Behavioral: Eccentric Viewing TrainingBehavioral: Sham

Arm 7

ACTIVE COMPARATOR

Group 7 - Monotherapy Treatment

Behavioral: NVT Eye Scanning TherapyBehavioral: Sham

Interventions

Therapy that enhances the neuronal plasticity of the visual system

Arm 1Arm 3Arm 5

Therapy that trains eye and head scanning into the blind hemianoptic visual field

Arm 1Arm 3Arm 7

Therapy that trains the person to compensate for visual field loss by learning to move the visual field loss to the position that is least likely to impact the current visual task

Arm 2Arm 4Arm 6
ShamBEHAVIORAL

Therapy that encourages subjects to do daily visual tasks at home while having no training or intended intervention benefit

Arm 5Arm 6Arm 7

Eligibility Criteria

Age20 Years - 79 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • TBI (any form)
  • Hemianopic Visual Field Loss
  • Stable fixation
  • logMAR or better Reading Acuity
  • words per minute or better reading rate

You may not qualify if:

  • Visual Neglect
  • medical conditions that prevent sitting for 30 minutes or following instructions

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

VA Palo Alto Health Care System

Palo Alto, California, 94304-1290, United States

Location

MeSH Terms

Conditions

Brain Injuries

Interventions

salicylhydroxamic acid

Condition Hierarchy (Ancestors)

Brain DiseasesCentral Nervous System DiseasesNervous System DiseasesCraniocerebral TraumaTrauma, Nervous SystemWounds and Injuries

Study Officials

  • Ron Schuchard, PhD

    VA Palo Alto Health Care System

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
phase 4
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
CROSSOVER
Sponsor Type
FED
Responsible Party
SPONSOR

Study Record Dates

First Submitted

September 14, 2010

First Posted

October 4, 2010

Study Start

June 1, 2012

Primary Completion

November 21, 2013

Study Completion

November 21, 2013

Last Updated

June 16, 2017

Record last verified: 2017-06

Locations