Revitalization of Teeth With Necrotic Pulps and Open Apexes Using Platelet-Rich Plasma

NCT01212939 | Terminated

• 1 other identifier: IRB# 5100239
• Study Type: observational
• Target: 10
• Locations: 1 country
• Sites: 2

Brief Summary

When root canals of infected teeth with closed ends are cleaned, disinfected and filled, the results are predictable with excellent outcomes. However, in a tooth with incomplete root development, the end of the root(s) must be closed before filling the root canals. One or two-step artificial barrier using mineral trioxide aggregate (MTA) has been used before filling the root canals of these teeth. Despite the high success of this treatment, this procedure does not result in complete root formation and these teeth are susceptible to root fracture. A number of case reports in scientific journal have shown the possibility for regeneration of nerve within the root canal space and continued root development in teeth with dead nerves and open ends. There is very little information regarding the use of stem cells and growth factors from the blood of patients to regenerate the nerves in these teeth. Platelet rich plasma (PRP) from whole blood has been mentioned in the literature as a potential ideal material for regeneration of nerves in these teeth. The purpose of this study is to investigate the use of PRP to regenerate tooth nerve and close the root ends in teeth with root canal infection and open root ends.

Conditions

Infection

Keywords

Dead pulps and open root ends; Patients who have teeth with dead pulp and open root ends

Outcome Measures

Primary Outcomes (1)

• stop the infection

  6 weeks

Secondary Outcomes (1)

• Revitalizing the nerve of the tooth

  Every 3-6 months for two years

Eligibility Criteria

• Age: 6 Years - 89 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All patients between the ages of 6-89

You may qualify if:

• People with necrotic pulp and open apex.

You may not qualify if:

• People with vital pulp and closed apexes

Sponsors & Collaborators

• Torabinejad, Mahmoud: lead

Study Sites (2)

Loma Linda Dental School

Loma Linda, California, 92350, United States

Location

Loma Linda University

Loma Linda, California, 92354, United States

Location

MeSH Terms

Conditions

Infections

Study Officials

• Mahmoud Torabinejad, DDS

  Loma Linda University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: September 29, 2010
• First Posted: October 1, 2010
• Study Start: October 1, 2012
• Primary Completion: December 1, 2013
• Study Completion: December 1, 2013
• Last Updated: April 4, 2014

Record last verified: 2014-04

Locations

US (2)