Mediators of Atherosclerosis in South Asians Living in America
MASALA
4 other identifiers
observational
2,314
1 country
3
Brief Summary
South Asian (Indian, Pakistani, Bangladeshi, Nepali, and Sri Lankan) individuals have high rates of cardiovascular disease that is not explained by traditional cardiovascular risk factors. Though South Asians represent over one-quarter of the world's population, there are no longitudinal studies in this high-risk ethnic group. The investigators aim to establish a longitudinal study of South Asians at three United States centers to identify risk factors linked to subclinical atherosclerosis and incident cardiovascular disease. The purpose of this study is to understand the causes of heart disease and stroke in South Asians and compare these causes to those in other United States ethnic groups.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Sep 2010
Longer than P75 for all trials
3 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 1, 2010
CompletedFirst Submitted
Initial submission to the registry
September 21, 2010
CompletedFirst Posted
Study publicly available on registry
September 22, 2010
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 1, 2013
CompletedStudy Completion
Last participant's last visit for all outcomes
April 1, 2027
ExpectedJanuary 26, 2026
January 1, 2026
2.5 years
September 21, 2010
January 22, 2026
Conditions
Outcome Measures
Primary Outcomes (1)
Coronary artery calcium prevalence in South Asians
Baseline
Secondary Outcomes (4)
Carotid intima media thickness
Baseline
Diabetes Prevalence
Baseline
Change from baseline Coronary artery calcium prevalence in South Asians at 4 years
Baseline to Year 4
Incidence of type 2 diabetes after approximately 4 years of follow-up
Baseline to Year 4
Eligibility Criteria
South Asians (individuals from India, Pakistan, Nepal, Bangladesh, and Sri Lanka) adults between the ages of 40 and 84 years without cardiovascular disease living in the San Francisco Bay Area, Chicago Area, or New York City Area.
You may qualify if:
- South Asian ancestry defined by having at least 3 grandparents born in one of the following countries: India, Pakistan, Bangladesh, Nepal, or Sri Lanka
- age between 40 and 84 years.
You may not qualify if:
- Physician diagnosed heart attack, stroke or transient ischemic attack (TIA), heart failure, or angina (or use of nitroglycerin)
- Current atrial fibrillation
- Past history of cardiovascular procedures (coronary artery bypass graft (CABG) Surgery, angioplasty, valve replacement, pacemaker or defibrillator implantation, or any surgery on the heart or arteries)
- Active treatment for cancer
- Life expectancy less than 5 years due to serious medical illness
- Impaired cognitive ability as judged by the reviewer
- Plans to move out of the study region in next 5 years
- Weight greater than 300 pounds
- Living in a nursing home or on a waiting list
- Unable to speak/read/write English, Hindi, Urdu, or Bangla
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- National Institute on Minority Health and Health Disparities (NIMHD)collaborator
- New York Universitycollaborator
- Northwestern Universitycollaborator
- University of California, San Franciscolead
- National Heart, Lung, and Blood Institute (NHLBI)collaborator
Study Sites (3)
University of California, San Francisco
San Francisco, California, 94115, United States
Northwestern University
Chicago, Illinois, 60611, United States
New York University
New York, New York, United States
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Alka Kanaya, MD
University of California, San Francisco
- PRINCIPAL INVESTIGATOR
Namratha Kandula, MD
Northwestern University
- PRINCIPAL INVESTIGATOR
Nadia Islam, PhD
New York University
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
September 21, 2010
First Posted
September 22, 2010
Study Start
September 1, 2010
Primary Completion
March 1, 2013
Study Completion (Estimated)
April 1, 2027
Last Updated
January 26, 2026
Record last verified: 2026-01
Data Sharing
- IPD Sharing
- Will not share