Screen of DM by OGTT in Subjects Receiving CAG or MDCT for CAD
Screen of Diabetes Mellitus by Oral Glucose Tolerance Test in Subjects Receiving Catheterization or Multi-detector Computed Tomography (MDCT) for Coronary Artery Disease
1 other identifier
observational
2,000
1 country
1
Brief Summary
To determine the glucose regulation status of patients who were suspected to have CAD in central Taiwan.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Apr 2009
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
April 1, 2009
CompletedFirst Submitted
Initial submission to the registry
September 8, 2010
CompletedFirst Posted
Study publicly available on registry
September 10, 2010
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2024
CompletedJanuary 7, 2020
January 1, 2020
11.7 years
September 8, 2010
January 4, 2020
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Diabetes
Based on OGTT and HbA1c
3 months
Secondary Outcomes (3)
Brain-derived neurotrophic factor
3 months
Coroanry artery disease
3 months
Mortality
5 years
Eligibility Criteria
In this prospective observational study, we screened adult patients admitted for coronary angiography due to angina
You may qualify if:
- Patient received CAG or MDCT for suspect CAD
- Without DM history
You may not qualify if:
- Known DM
- Unstable disease condition
- Pregnancy
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Taichung Veterans General Hospital
Taichung, 40705, Taiwan
Related Publications (4)
Liang KW, Lee WJ, Lee IT, Lee WL, Wang JS, Wu JP, Sheu WH. Subjects with microvascular angina have longer GT repeats polymorphism in the haem oxygenase-1 gene promoter. Biomarkers. 2020 Mar;25(2):144-148. doi: 10.1080/1354750X.2020.1713214. Epub 2020 Jan 20.
PMID: 31916865DERIVEDLiang KW, Sheu WH, Lee WJ, Lee WL, Fu CP, Wang JS. Differential expression of circulating vascular cell adhesion molecule-1 in subjects with coronary artery disease and cardiac syndrome X without known diabetes mellitus. Biomarkers. 2017 Dec;22(8):798-804. doi: 10.1080/1354750X.2017.1351003. Epub 2017 Jul 18.
PMID: 28675064DERIVEDLiang KW, Sheu WH, Lee WJ, Lee WL, Pan HC, Lee IT, Wang JS. Post-challenge insulin concentration is useful for differentiating between coronary artery disease and cardiac syndrome X in subjects without known diabetes mellitus. Diabetol Metab Syndr. 2017 Feb 8;9:10. doi: 10.1186/s13098-017-0209-1. eCollection 2017.
PMID: 28194232DERIVEDWang JS, Lee IT, Lee WJ, Lin SY, Fu CP, Ting CT, Lee WL, Liang KW, Sheu WH. Performance of HbA1c and fasting plasma glucose in screening for diabetes in patients undergoing coronary angiography. Diabetes Care. 2013 May;36(5):1138-40. doi: 10.2337/dc12-1434. Epub 2012 Dec 13.
PMID: 23238660DERIVED
Biospecimen
Blood samples were collected during OGTT after an overnight fasting
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Wayne H-H Sheu, MD, PHD
Taichung Veterans General Hospital
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Chief in Internal medicine department
Study Record Dates
First Submitted
September 8, 2010
First Posted
September 10, 2010
Study Start
April 1, 2009
Primary Completion
December 1, 2020
Study Completion
December 1, 2024
Last Updated
January 7, 2020
Record last verified: 2020-01