The Relationship Between Dietary Habit and Gastroesophageal Flap Valve Abnormality

NCT01194544 | Unknown

• 1 other identifier: 99033
• Study Type: observational
• Target: 600
• Locations: 1 country
• Sites: 1

Brief Summary

Gastroesophageal reflux disease (GERD) is commonly seen in Western countries; however, it is gaining prevalence in Asia countries recently. In addition to the lower esophageal sphincter and the crural fibers of the diaphragm, the flap valve at the gastroesophageal junction is also responsible for maintaining an antireflux barrier. Hill et al developed a grading system of gastroesophageal flap valve (GEFV) and concluded that this flap valve system is simple, reproducible, and offers diagnostic aid in the evaluation of patients with suspicious reflux disease undergoing esophagogastroduodenoscopy (EGD). It is a common belief that large meals provoke considerable postprandial reflux and it results from an increase in the rate of transient lower esophageal sphincter relaxations. One study also revealed that rapid food intake produces more gastroesophageal reflux in healthy volunteers. So this study attempted to evaluate the relationship between dietary habit and GEFV abnormality. The investigators used a questionnaire regarding the dietary habit to the population undergoing EGD in a self-paid health examination.

Conditions

Healthy Subjects

Outcome Measures

Primary Outcomes (2)

• Grading of Gastroesophageal Flap Valve by Esophagoduodenoscopy

  1 year

• Dietary habit questionnaire

  1 year

Study Arms (1)

population undergoing EGD in health examination.

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

healthy subjects

You may qualify if:

• The healthy subjects undergo EGD in a self-paid health examination in WanFang Hospital.

You may not qualify if:

• None

Sponsors & Collaborators

• Taipei Medical University WanFang Hospital: lead

Study Sites (1)

Yung-Fa Chen

Taipei, Taipei, 116, Taiwan

RECRUITING

Study Officials

• Yung-Fa Chen, M.D.

  Taipei Medical University WanFang Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: August 10, 2010
• First Posted: September 3, 2010
• Study Start: August 1, 2010
• Primary Completion: July 1, 2011
• Study Completion: December 1, 2011
• Last Updated: March 8, 2011

Record last verified: 2011-03

Locations

TW (1)