Bipolar Disorder With Alcoholism in Han Chinese

NCT01188395 | Unknown DMC

• 1 other identifier: HR-98-002
• Study Type: observational
• Target: 105
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to explore relation between the comorbidity of different bipolar disorders with alcoholism and neuropsychiatric function and candidate genes. The investigators plan to establish genetic validity for this subtype of alcoholism. In addition, by comparing this subtyped alcoholism to normal control, the investigators plan to examine the genetic validity of such comorbidity. The investigators plan to find specific clinical characteristic from neuropsychiatric aspects of such subtype for future early diagnosis, prediction and prevention.

Conditions

Bipolar Disorders

Outcome Measures

Primary Outcomes (2)

• Young's Mania Rating Scale (YMRS)

  The severity of manic symptoms of patients will be rated by using YMRS.

  baseline, 3 months

• Hamilton Depression Rating Scale (HDRS)

  The severity of depressive symptoms of patients will be measured using HDRS.

  baseline, 3 months

Secondary Outcomes (2)

• blood sample

  baseline, 3 months

• DNA

  baseline

Study Arms (1)

subtypes of bipolar disorders

Bipolar I Disorder with alcoholism Bipolar I Disorder without alcoholism Bipolar II Disorder with alcoholism Bipolar II Disorder without alcoholism

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Bipolar disorders

You may qualify if:

• Signed informed consent by patient or legal representative.
• Male or female patient aged ≧18 and ≦65 years.
• A diagnosis of Bipolar I or Bipolar II Disorder according to DSM-IV criteria made by a specialist in psychiatry.
• Patients who were diagnosed with alcohol dependence or abuse according to DSM-IV criteria made by a specialist in psychiatry.

You may not qualify if:

• Patients, except those are Bipolar disorder with alcoholsim who were diagnosed substance abuse/depence
• Patients with brain injury or regrated neurological diseases
• Patients who are with I axis major mental illess according to DSM-IV criteria

Sponsors & Collaborators

• National Cheng-Kung University Hospital: lead
• National Science and Technology Council, Taiwan: collaborator

Study Sites (1)

Ru-Band Lu

Tainan, 704, Taiwan

RECRUITING

MeSH Terms

Conditions

Bipolar Disorder

Condition Hierarchy (Ancestors)

Bipolar and Related Disorders; Mood Disorders; Mental Disorders

Study Officials

• Ru-Band Lu, MD

  National Cheng-Kung University Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Ru-Band Lu, MD

CONTACT

+886-6-2353535; rblu@mail.ncku.edu.tw

Study Design

• Study Type: observational
• Observational Model: ECOLOGIC OR COMMUNITY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: August 23, 2010
• First Posted: August 25, 2010
• Study Start: August 1, 2009
• Primary Completion: July 1, 2012
• Study Completion: July 1, 2012
• Last Updated: August 25, 2010

Record last verified: 2010-08

Locations

TW (1)