Tailored Internet-delivered Cognitive Behaviour Therapy for Symptoms of Depression and Comorbid Problems
TAYLOR1
Efficacy Testing of a Tailored Internet-delivered Cognitive Behaviour Therapy Treatment for Symptoms of Depression and Comorbid Problems
1 other identifier
interventional
121
1 country
1
Brief Summary
The overall aim of this study is to develop and test a tailored Internet-delivered psychological treatment for patients with mild to moderate major depression and comorbid anxiety symptoms and compare its efficacy to a non-tailored treatment and to an active control group.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable depression
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
August 9, 2010
CompletedFirst Posted
Study publicly available on registry
August 13, 2010
CompletedDecember 28, 2010
December 1, 2010
August 9, 2010
December 27, 2010
Conditions
Outcome Measures
Primary Outcomes (5)
Beck Depression Inventory (BDI)
One week before the treatment starts
Beck Depression Inventory (BDI)
Five weeks after treatment started
Beck Depression Inventory (BDI)
At treatment termination (10 weeks)
Beck Depression Inventory (BDI)
6 month after treatment ended
Beck Depression Inventory (BDI)
2 years after treatment ended
Secondary Outcomes (15)
Beck Anxiety Inventory (BAI)
One week before the treatment starts
Montgomery Åsberg Depression Rating Scale Self-report (MADRS-S)
One week before the treatment starts
Quality of Life Inventory (QOLI)
One week before the treatment starts
Beck Anxiety Inventory (BAI)
Five weeks after treatment started
Beck Anxiety Inventory (BAI)
At treatment termination (10 weeks)
- +10 more secondary outcomes
Study Arms (3)
Tailored Internet-delivered CBT
EXPERIMENTALNon-tailored Internet-delivered CBT
EXPERIMENTALOnline discussion group
ACTIVE COMPARATORInterventions
This intervention contains 8-10 text-based self-help modules in which 4 modules are fixed (the first three and the last) and the rest are "prescribed following the diagnostic telephone interview. These modules contain material on panic disorder, social phobia, stress management, assertiveness training, concentration, relaxation among other things.
Specific text-based self-help for depression, which has previously been tested in three previous randomized trials. Anxiety symptoms will not be covered, but insomnia is included as a module together with advice on health.
Participants take part of an online discussion group which are monitored daily. New discussion topics on depression are introduced every week.
Eligibility Criteria
You may qualify if:
- Clinical diagnosis of Major Depressive Disorder
- or more on MADRS-S
You may not qualify if:
- Severe depression (more than 35 on MADRS-S or based on interview)
- Severe psychiatric condition (e.g. psychosis or bipolar disorder)
- Changed medication during the last three months
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Linköping University, Department of Behavioral Sciences and Learning
Linköping, Sweden
Related Publications (1)
Johansson R, Sjoberg E, Sjogren M, Johnsson E, Carlbring P, Andersson T, Rousseau A, Andersson G. Tailored vs. standardized internet-based cognitive behavior therapy for depression and comorbid symptoms: a randomized controlled trial. PLoS One. 2012;7(5):e36905. doi: 10.1371/journal.pone.0036905. Epub 2012 May 15.
PMID: 22615841DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Gerhard Andersson, PhD
Department of Behavioral Sciences and Learning, Linköping University
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER GOV
Study Record Dates
First Submitted
August 9, 2010
First Posted
August 13, 2010
Last Updated
December 28, 2010
Record last verified: 2010-12