A Dangerous Triad in Ageing and in Chronic Obstructive Pulmonary Disease (COPD) - Reduced Muscle Mass, Impaired Muscle Function and Malnutrition

NCT01179178 | Completed

• 2 other identifiers: UGOTTriadGrant
• Study Type: observational
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

The investigators have taken part in the development of simple muscle function tests and studied physical training and energy turnover in patients with chronic obstructive pulmonary disease, COPD. The investigators have found that muscle wasting in COPD is related to poor prognosis and that physical training might lead to improved, less energy-demanding muscle function. Elderly subjects also suffer from muscle wasting that leads to frailty, poor autonomy and, secondarily, fractures. In the planned study the investigators will validate simple muscle function tests (hand grip strength, heel rise test, voluntary quadriceps muscle strength, 30 m walking test and balance tests) in both groups by relating them to an involuntary, magnet stimulated, test of quadriceps force, HRQL, tests of body composition (impedance, DXA) and recordings of physical activity. The relation between food intake, systemic inflammation, muscle mass and function will be analysed. The study has been ethically approved and started in COPD patients and will be expanded to a representative sample of elderly. Simple, evaluated muscle function tests applied in primary care may be used for early detection of muscle dysfunction in COPD patients and elderly so that early intervention against impaired muscle function can be started. Analyses of food intake and of inflammatory markers might identify factors of special importance for muscle dysfunction, which eventually might lead to improved dietary therapy and pharmacological interventions.

Conditions

Pulmonary Disease, Chronic Obstructive

Study Arms (2)

COPD-patients

Older adults (65-81 y)

Eligibility Criteria

• Age: 65 Years - 81 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Outpatients (COPD) and older adults living in Gothenburg

You may qualify if:

• Women and men between 65 and 81 years of age, randomly selected from the national registration, are invited to take part in the study.
• Patients referred to the outpatient clinic of the lung unit at Sahlgrenska University Hospital with a diagnosis of COPD are asked for participation.
• Clinical diagnosis of COPD
• FEV% \< normal value minus 2 SD
• Smoking history; 10 pack years or more

You may not qualify if:

• Any specific muscular disease
• Severe disease or handicap making investigations impossible
• Any specific muscular disease
• Any co-existing serious disease

Sponsors & Collaborators

• Göteborg University: lead
• The Swedish Research Council: collaborator
• The Swedish Heart and Lung Association: collaborator
• Swedish Heart Lung Foundation: collaborator

Study Sites (1)

Dept of Clinical Nutrition, Sahlgrenska Academy at University of Gothenburg

Gothenburg, 44232, Sweden

Location

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: August 9, 2010
• First Posted: August 11, 2010
• Study Start: March 1, 2006
• Primary Completion: December 1, 2009
• Study Completion: December 1, 2009
• Last Updated: August 11, 2010

Record last verified: 2006-01

Locations

SE (1)