Exploring the Role of Adipocyte Fatty Acid Binding Protein in the Association of Obstructive Sleep Apnea and Metabolic Dysfunction

NCT01173432 | Completed DMC

• 2 other identifiers: UW07-178HKCTR-770
• Study Type: interventional
• Target: 90
• Locations: 1 country
• Sites: 1

Brief Summary

Adipocyte fatty acid binding protein (A-FABP) is a member of the FABP super family, is abundant in adipocytes and macrophages. Regulatory functions of A-FABP in lipid and glucose metabolism have been described, and it is suggested to play an important role in the pathogenesis of metabolic syndrome.We hypothesize that obstructive sleep apnea (OSA) may upregulate A-FABP production and thus causally contribute to metabolic dysfunction. Our group has recently demonstrated that A-FABP, expressed and secreted from adipocytes, is present in the blood stream .The levels of A-FABP correlated with various metabolic variates in the metabolic syndrome. Furthermore, we have obtained novel data in men with a range of sleep disordered breathing showed that the duration of oxygen desaturation correlated with circulating levels of A-FABP, independent of age and waist/body mass index. The current proposal aims to pursue this finding and further explore the role of A-FABP in the association of OSA and metabolic dysfunction.

Conditions

Obstructive Sleep Apnea; Insulin Resistance; Metabolic Syndrome; Inflammation

Keywords

obstructive sleep apnea; metabolic dysfunction; metabolic syndrome; adipocyte fatty acid binding protein

Outcome Measures

Primary Outcomes (1)

• adipocyte fatty acid binding protein

  blood assay

  changes over 4 weeks of CPAP treatment

Secondary Outcomes (6)

• Insulin and glucose

  changes over 4 weeks of CPAP treatment

• Lipids and lipoprotein

  changes over 4 weeks of CPAP treatment

• blood Markers of oxidative stress and fat metabolism

  changes over 4 weeks of CPAP treatment

• blood inflammatory markers

  changes over 4 weeks of CPAP treatment

• blood pressure

  changes over 4 weeks of CPAP treatment

Study Arms (2)

continuous positive airway pressure

ACTIVE COMPARATOR

using continuous positive airway pressure (CPAP) device during sleep, for the study period (4 weeks)

Device: continuous positive airway pressure

control

NO INTERVENTION

observation for the study period (4 weeks, no CPAP)

Interventions

continuous positive airway pressure DEVICE

an device to be used during sleep, which was a nasal mask connected to a device with pressure applied to upper airway

continuous positive airway pressure

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Subjects between 18 - 65 years old
• Able to understand and give informed written consent

You may not qualify if:

• BMI \> 35 kg/m2, and features of obesity hypoventilation syndrome
• known diabetes mellitus or hyperlipidemia on treatment
• known cardiovascular disease except hypertension stable on treatment
• unstable medical illness
• need for starting treatment for OSA or other medical conditions immediately

Sponsors & Collaborators

• The University of Hong Kong: lead

Study Sites (1)

The University of Hong Kong

Hong Kong, 852, Hong Kong

Location

Related Publications (4)

• Xu A, Wang Y, Xu JY, Stejskal D, Tam S, Zhang J, Wat NM, Wong WK, Lam KS. Adipocyte fatty acid-binding protein is a plasma biomarker closely associated with obesity and metabolic syndrome. Clin Chem. 2006 Mar;52(3):405-13. doi: 10.1373/clinchem.2005.062463. Epub 2006 Jan 19.

  PMID: 16423904 BACKGROUND

• Stejskal D, Karpisek M. Adipocyte fatty acid binding protein in a Caucasian population: a new marker of metabolic syndrome? Eur J Clin Invest. 2006 Sep;36(9):621-5. doi: 10.1111/j.1365-2362.2006.01696.x.

  PMID: 16919044 BACKGROUND

• Lam DC, Xu A, Lam KS, Lam B, Lam JC, Lui MM, Ip MS. Serum adipocyte-fatty acid binding protein level is elevated in severe OSA and correlates with insulin resistance. Eur Respir J. 2009 Feb;33(2):346-51. doi: 10.1183/09031936.50075408.

  PMID: 19181913 BACKGROUND

• Lui MMS, Mak JCW, Chong PWC, Lam DCL, Ip MSM. Circulating adipocyte fatty acid-binding protein is reduced by continuous positive airway pressure treatment for obstructive sleep apnea-a randomized controlled study. Sleep Breath. 2020 Sep;24(3):817-824. doi: 10.1007/s11325-019-01893-5. Epub 2019 Aug 1.

  PMID: 31372823 DERIVED

MeSH Terms

Conditions

Sleep Apnea, Obstructive; Insulin Resistance; Metabolic Syndrome; Inflammation

Interventions

Continuous Positive Airway Pressure

Condition Hierarchy (Ancestors)

Sleep Apnea Syndromes; Apnea; Respiration Disorders; Respiratory Tract Diseases; Sleep Disorders, Intrinsic; Dyssomnias; Sleep Wake Disorders; Nervous System Diseases; Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Positive-Pressure Respiration; Respiration, Artificial; Airway Management; Therapeutics; Respiratory Therapy

Study Officials

• Mary SM Ip, MD

  The University of Hong Kong, Queen Mary Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: July 29, 2010
• First Posted: August 2, 2010
• Study Start: June 1, 2008
• Primary Completion: December 1, 2018
• Study Completion: December 1, 2018
• Last Updated: April 17, 2019

Record last verified: 2019-04

Locations

HK (1)