Iowa Healthy and Active Minds Study
IHAMS
RCT of Two Speed of Processing Modes to Prevent Cognitive Decline in Older Adults
2 other identifiers
interventional
681
1 country
1
Brief Summary
This is second-generation study based on results from ACTIVE (Advanced Cognitive Training for Independent and Vital Elderly). This four-arm study is known as IHAMS (the Iowa Healthy and Active Minds Study). The investigators will formally test from an intent-to-treat perspective for differences on the primary and secondary outcomes based on whether participants were randomized to the basic on-site speed of processing training (SOPT) group (G1), to the on-site basic SOPT plus subsequent booster-training group (G2), to the basic at-home SOPT group (G3), or to the basic attention-control group (G4). Basic training involves 10 hours of either the SOPT or attention-control training during the first 6 weeks of participation. Booster-training involves 4 additional hours of SOPT training at 11 months of participation.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Sep 2009
Typical duration for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 1, 2009
CompletedFirst Submitted
Initial submission to the registry
July 13, 2010
CompletedFirst Posted
Study publicly available on registry
July 19, 2010
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2011
CompletedStudy Completion
Last participant's last visit for all outcomes
March 1, 2012
CompletedJune 21, 2019
June 1, 2019
2.2 years
July 13, 2010
June 19, 2019
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Useful Field of View Test
The Useful Field of View (UFOV) is a computer-administered test of functional vision and visual attention. UFOV consists of three subtests which assess speed of visual processing under increasingly complex task demands. The examinee must detect, identify, and localize briefly presented targets.
12 months
Secondary Outcomes (5)
Digit Vigilance Test
12 months
Symbol Digit Modalities Test
12 Months
Controlled Oral Word Association Test
12 Months
Comprehensive Trail Making Test
12 Months
Stroop
12 months
Study Arms (4)
Clinic-based SOPT basic training
EXPERIMENTALClinic-based SOPT basic training for 10 hours.
Home-based SOPT basic training
EXPERIMENTALHome-based SOPT basic training for 10 hours.
Crossword Puzzles Training
ACTIVE COMPARATORCrossword puzzles training for 10 hours in our lab.
SOPT basic and SOPT booster-training
EXPERIMENTALClinic-based SOPT basic training and SOPT booster training.
Interventions
10 hours of basic training
4 hours of subsequent booster-training
Eligibility Criteria
You may qualify if:
- years of age or older
- Patient of the FCC in Family Medicine or General Internal Medicine Clinic at UIHC
- No known memory problems
You may not qualify if:
- Significant vision impairments
- Lack of access to a computer or owns a MAC
- Lives more than 37 miles from the lab
- Traumatic Brain Injury or severe stroke
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Fredric D Wolinskylead
- National Institute on Aging (NIA)collaborator
Study Sites (1)
University of Iowa
Iowa City, Iowa, 52242, United States
Related Publications (5)
Wolinsky FD, Vander Weg MW, Howren MB, Jones MP, Martin R, Luger TM, Duff K, Goerdt C, Wolfe S, Dotson MM. Protocol for a randomised controlled trial to improve cognitive functioning in older adults: the Iowa Healthy and Active Minds Study. BMJ Open. 2011 Jan 1;1(2):e000218. doi: 10.1136/bmjopen-2011-000218.
PMID: 22021885BACKGROUNDWolinsky FD, Vander Weg MW, Howren MB, Jones MP, Martin R, Luger TM, Duff K, Dotson MM. Interim analyses from a randomised controlled trial to improve visual processing speed in older adults: the Iowa Healthy and Active Minds Study. BMJ Open. 2011 Nov 21;1(2):e000225. doi: 10.1136/bmjopen-2011-000225. Print 2011.
PMID: 22106377RESULTWolinsky FD, Vander Weg MW, Howren MB, Jones MP, Dotson MM. A randomized controlled trial of cognitive training using a visual speed of processing intervention in middle aged and older adults. PLoS One. 2013 May 1;8(5):e61624. doi: 10.1371/journal.pone.0061624. Print 2013.
PMID: 23650501RESULTWolinsky FD, Vander Weg MW, Howren MB, Jones MP, Dotson MM. The effect of cognitive speed of processing training on the development of additional IADL difficulties and the reduction of depressive symptoms: results from the IHAMS randomized controlled trial. J Aging Health. 2015 Mar;27(2):334-54. doi: 10.1177/0898264314550715. Epub 2014 Sep 19.
PMID: 25239928RESULTWolinsky FD, Vander Weg MW, Howren MB, Jones MP, Dotson MM. Effects of cognitive speed of processing training on a composite neuropsychological outcome: results at one-year from the IHAMS randomized controlled trial. Int Psychogeriatr. 2016 Feb;28(2):317-30. doi: 10.1017/S1041610215001428. Epub 2015 Sep 14.
PMID: 26364892DERIVED
Study Officials
- PRINCIPAL INVESTIGATOR
Fredric D Wolinksy, Ph.D.
University of Iowa
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- INVESTIGATOR
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR INVESTIGATOR
- PI Title
- Professor of Public Health
Study Record Dates
First Submitted
July 13, 2010
First Posted
July 19, 2010
Study Start
September 1, 2009
Primary Completion
December 1, 2011
Study Completion
March 1, 2012
Last Updated
June 21, 2019
Record last verified: 2019-06
Data Sharing
- IPD Sharing
- Will not share