Preoperative Resistance Training in Patients Scheduled for Total Hip Arthroplasty

NCT01164111 | Completed DMC

• 1 other identifier: H-4-2010-034
• Study Type: interventional
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

Purpose: The purpose of this study is to determine the effect of pre operative resistance training on subjects scheduled for total hip arthroplasty due to primary osteoarthritis. Background: Decreasing performance with age due to age related muscle loss is well known. Resistance training in elderly has shown significant effect in regaining both muscle force and function. It has been shown that a chronic condition with limitations in function as seen in osteoarthritis of the hip decreases both muscle performance and size. Studies of resistance training of the hip related muscle groups in the early postoperative period after total hip arthroplasty have shown significant effect on muscle force and function. Few studies have investigated preoperative intervention, all with lighter types of training such as water pool training. The effect of preoperative resistance training on subjects with primal osteoarthritis of the hip is yet to be described. Study hypothesis: Preoperative resistance training will significant improve outcomes on both primal and secondary effect parameters pre surgery and at 1 year followup.

Conditions

Osteoarthritis

Keywords

osteoarthritis; hip arthroplasty; resistance training; preoperative training

Outcome Measures

Primary Outcomes (6)

• Hip dysfunction and Osteoarthritis Outcome Score (HOOS function -daily living)

  Questionnaire on Hip Dysfunktion. Rated questions on: * symptoms * stiffness * pain * function - daily living * function - sports and recreational activities. The questionnaire is validated (compared to WOMAC) in patients with oateoarthritis in the hip - both pre- and postoperative.

  0 weeks (entrypoint =T0)

• Hip dysfunction and Osteoarthritis Outcome Score (HOOS function -daily)

  Questionnaire on Hip Dysfunktion. Rated questions on: * symptoms * stiffness * pain * function - daily living * function - sports and recreational activities. The questionnaire is validated (compared to WOMAC) in patients with oateoarthritis in the hip - both pre- and postoperative.

  8 weeks (T1 pre surgery)

• Hip dysfunction and Osteoarthritis Outcome Score (HOOS function - daily living)

  Questionnaire on Hip Dysfunktion. Rated questions on: * symptoms * stiffness * pain * function - daily living * function - sports and recreational activities. The questionnaire is validated (compared to WOMAC) in patients with oateoarthritis in the hip - both pre- and postoperative.

  3 months (T3 -post surgery)

• Hip dysfunction and Osteoarthritis Outcome Score (HOOS function - daily living)

  Questionnaire on Hip Dysfunktion. Rated questions on: * symptoms * stiffness * pain * function - daily living * function - sports and recreational activities. The questionnaire is validated (compared to WOMAC) in patients with oateoarthritis in the hip - both pre- and postoperative.

  6 months (T4 - postsurgery)

• Hip dysfunction and Osteoarthritis Outcome Score (HOOS function - daily living)

  Questionnaire on Hip Dysfunktion. Rated questions on: * symptoms * stiffness * pain * function - daily living * function - sports and recreational activities. The questionnaire is validated (compared to WOMAC) in patients with oateoarthritis in the hip - both pre- and postoperative

  9 months (T5 -post surgery)

• Hip dysfunction and Osteoarthritis Outcome Score (HOOS function - daily living)

  Questionnaire on Hip Dysfunktion. Rated questions on: * symptoms * stiffness * pain * function - daily living * function - sports and recreational activities. The questionnaire is validated (compared to WOMAC) in patients with oateoarthritis in the hip - both pre- and postoperative

  12 months (endpoint - post surgery)

Secondary Outcomes (28)

• Muscle Power

  0 weeks (pre surgery)

• Muscle strength

  0 weeks (pre surgery)

• Functional scores

  0 weeks (pre surgery)

• Body composition: Dual Energy X-ray Absorptiometry scan(DEXA scan)

  0 weeks (pre surgery

• Activity score: Metabolic equivalent score (MET- score)

  0 weeks (pre surgery)

Study Arms (2)

Preoperative resistance training

EXPERIMENTAL

preoperative resistance training: Duration 8 weeks. Intensity: 3 sets of 80 % of 1 repetition max (1 RM) in each exercise. Frequency: 2 times/week

Other: Preoperative resistance training

Control

NO INTERVENTION

Standard preoperative track.: No training intervention. Standard preoperative information.

Interventions

Preoperative resistance training OTHER

preoperative resistance training: Duration 8 weeks. Intensity: 3 sets of 80 % of 1 repetition max (1 RM) in each exercise (stated as 8-10 repetitions of the exercise). Frequency: 2 times/week. The patient follows a special training program consisting of exercises with knee and hip extension. Training intensity is followed in a personalized log-book for each patient. Sessions are conducted in small teams closely supervised by specially trained physiotherapists.

Preoperative resistance training

Eligibility Criteria

• Age: 50 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• All patients scheduled for total hip arthroplasty due to primary osteoarthritis with an age of 50 years or older.
• Patients in the intervention group must participate in 80% of the training as a minimum and more than 2 skipped sessions in a row is not allowed.

You may not qualify if:

• Rheumatoid arthritis (RA) or other types of arthritis other than primary osteoarthritis.
• Uremia
• Cancer
• Systemic treatment with glucocorticoid more than 3 months the last 5 years with a daily dose \> 5 mg.
• Fracture of the hip (ipsi or contralateral)
• Other fracture of the lower extremities the last year
• Other condition with reduced function (ex polio seq.)
• Weight above 135 kg

Sponsors & Collaborators

• University of Southern Denmark: lead
• University of Copenhagen: collaborator

Study Sites (1)

Ortopædkirurgisk Afdeling T Herlev Hospital

Herlev, 2730, Denmark

Location

Related Publications (36)

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• Holsgaard-Larsen A, Hermann A, Zerahn B, Mejdahl S, Overgaard S. Effects of progressive resistance training prior to total HIP arthroplasty - a secondary analysis of a randomized controlled trial. Osteoarthritis Cartilage. 2020 Aug;28(8):1038-1045. doi: 10.1016/j.joca.2020.04.010. Epub 2020 May 4.

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• Hermann A, Holsgaard-Larsen A, Zerahn B, Mejdahl S, Overgaard S. Preoperative progressive explosive-type resistance training is feasible and effective in patients with hip osteoarthritis scheduled for total hip arthroplasty--a randomized controlled trial. Osteoarthritis Cartilage. 2016 Jan;24(1):91-8. doi: 10.1016/j.joca.2015.07.030. Epub 2015 Aug 15.

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MeSH Terms

Conditions

Osteoarthritis

Condition Hierarchy (Ancestors)

Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases

Study Officials

• Andreas EB Hermann, MD

  University of Southern Denmark

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD

Study Record Dates

• First Submitted: July 12, 2010
• First Posted: July 16, 2010
• Study Start: October 1, 2010
• Primary Completion: September 1, 2013
• Study Completion: September 1, 2013
• Last Updated: October 12, 2015

Record last verified: 2015-10

Locations

DK (1)