Iron Absorption and Utilization in Adolescents Infected With Malaria Parasites, Hookworms or Schistosoma

NCT01163877 | Completed

• 1 other identifier: EK-2009-N-19
• Study Type: interventional
• Target: 43
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to investigate the change in iron metabolism in relation to malaria and helminth infections using a stable isotope technique.

Conditions

Malaria, Falciparum; Hookworm Infections; Schistosoma Haematobium

Keywords

iron absorption; iron utilization; malaria; helminth; Ivory Coast; Acute symptomatic uncomplicated falciparum malaria; Asymptomatic falciparum malaria; Moderate to heavy hookworm infection; Heavy Schistosoma haematobium infection

Outcome Measures

Primary Outcomes (2)

• Isotope absorption into blood stream

  Day 15

• Isotope absorption into blood stream

  Day 43

Secondary Outcomes (6)

• Isotope incorporation into erythrocytes

  Day 15

• Biochemical parameters of iron status and infection

  Day 1

• Biochemical parameters of iron status and infection

  Day 15

• Biochemical parameters of iron status and infection

  Day 29

• Biochemical parameters of iron status and infection

  Day 43

Study Arms (4)

Symptomatic malaria infection

OTHER

Dietary Supplement: Fe-57 orally, Fe-58 intravenously

Asymptomatic malaria infection

OTHER

Dietary Supplement: Fe-57 orally, Fe-58 intravenously

Hookworm infection

OTHER

Dietary Supplement: Fe-57 orally, Fe-58 intravenously

Schistosoma haematobium infection

OTHER

Dietary Supplement: Fe-57 orally, Fe-58 intravenously

Interventions

Fe-57 orally, Fe-58 intravenously DIETARY_SUPPLEMENT

Subjects will receive a test drink containing 3 mg Fe-57 in the form of labelled FeSO4 followed by 1 ml of an aqueous solution containing 50 μg Fe-58 as iron citrate.

Asymptomatic malaria infection; Hookworm infection; Schistosoma haematobium infection; Symptomatic malaria infection

Eligibility Criteria

• Age: 12 Years - 16 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)

You may qualify if:

• Children aged 12 to 16 years
• Body weight \> 30 kg
• no chronic medical illnesses
• no intake of vitamin/mineral supplements 2 weeks before the study and until the last blood drawing
• For each of the 4 arms the respective disease needs to be present (symptomatic malaria, asymptomatic malaria, hookworm infection, S. haematobium infection) without any other concurrent infection

Sponsors & Collaborators

• Swiss Federal Institute of Technology: lead

Study Sites (1)

Taabo Cité Hospital

Taabo, Côte d’Ivoire

Location

Related Publications (5)

• Rohner F, Zimmermann MB, Amon RJ, Vounatsou P, Tschannen AB, N'goran EK, Nindjin C, Cacou MC, Te-Bonle MD, Aka H, Sess DE, Utzinger J, Hurrell RF. In a randomized controlled trial of iron fortification, anthelmintic treatment, and intermittent preventive treatment of malaria for anemia control in Ivorian children, only anthelmintic treatment shows modest benefit. J Nutr. 2010 Mar;140(3):635-41. doi: 10.3945/jn.109.114256. Epub 2010 Jan 27.

  PMID: 20107144 BACKGROUND

• Wegmuller R, Camara F, Zimmermann MB, Adou P, Hurrell RF. Salt dual-fortified with iodine and micronized ground ferric pyrophosphate affects iron status but not hemoglobin in children in Cote d'Ivoire. J Nutr. 2006 Jul;136(7):1814-20. doi: 10.1093/jn/136.7.1814.

  PMID: 16772442 BACKGROUND

• Kastenmayer P, Davidsson L, Galan P, Cherouvrier F, Hercberg S, Hurrell RF. A double stable isotope technique for measuring iron absorption in infants. Br J Nutr. 1994 Mar;71(3):411-24. doi: 10.1079/bjn19940148.

  PMID: 8172870 BACKGROUND

• Walczyk T, Davidsson L, Zavaleta N, Hurrell RF. Stable isotope labels as a tool to determine the iron absorption by Peruvian school children from a breakfast meal. Fresenius Journal of Analytical Chemistry 359: 445-449, 1997.

  BACKGROUND

• Glinz D, Hurrell RF, Righetti AA, Zeder C, Adiossan LG, Tjalsma H, Utzinger J, Zimmermann MB, N'Goran EK, Wegmuller R. In Ivorian school-age children, infection with hookworm does not reduce dietary iron absorption or systemic iron utilization, whereas afebrile Plasmodium falciparum infection reduces iron absorption by half. Am J Clin Nutr. 2015 Mar;101(3):462-70. doi: 10.3945/ajcn.114.090175. Epub 2015 Feb 4.

  PMID: 25733630 DERIVED

MeSH Terms

Conditions

Malaria, Falciparum; Hookworm Infections; Schistosomiasis haematobia; Malaria

Condition Hierarchy (Ancestors)

Protozoan Infections; Parasitic Diseases; Infections; Mosquito-Borne Diseases; Vector Borne Diseases; Strongylida Infections; Secernentea Infections; Nematode Infections; Helminthiasis; Schistosomiasis; Trematode Infections; Urinary Tract Infections; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases

Study Officials

• Rita Wegmüller, Dr.

  Swiss Federal Institute of Technology (ETH) Zurich

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof

Study Record Dates

• First Submitted: July 14, 2010
• First Posted: July 16, 2010
• Study Start: April 1, 2010
• Primary Completion: September 1, 2013
• Study Completion: September 1, 2013
• Last Updated: October 14, 2013

Record last verified: 2013-10

Locations

CÔ (1)